Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients

Mohamed Salah El-Din Mahmoud, Mohamed A Hamid, Mohamed Farouk Abdelkader Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptEmail drmohamedhamid83@mu.edu.egPurp...

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Autores principales:	Mahmoud MSE, Hamid MA, Abdelkader MF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anterior segment optical coherence tomography tear film dry eye disease systemic lupus erythematous Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2efc7ef5da6441bcbde5467c5eed83eb
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spelling	oai:doaj.org-article:2efc7ef5da6441bcbde5467c5eed83eb2021-12-02T16:26:57ZAnterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients1177-5483https://doaj.org/article/2efc7ef5da6441bcbde5467c5eed83eb2021-08-01T00:00:00Zhttps://www.dovepress.com/anterior-segment-optical-coherence-tomography-of-tear-film-and-cornea--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Mohamed Salah El-Din Mahmoud, Mohamed A Hamid, Mohamed Farouk Abdelkader Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptEmail drmohamedhamid83@mu.edu.egPurpose: To study tear film and corneal thickness measurements in systemic lupus erythematosus (SLE) patients compared to age-matched controls using anterior segment optical coherence tomography (AS-OCT).Methods: This was a cross-sectional study. Study participants were divided into 3 groups: Group A: SLE patients with clinical dry eye, Group B: SLE patients without clinical dry eye and Group C: healthy controls. The lower tear meniscus parameters measured using AS-OCT were tear meniscus height (TMH), tear meniscus depth (TMD) and tear meniscus area (TMA). The central corneal and corneal epithelial thickness were automatically calculated.Results: The study included 40 eyes in Group A, 60 in Group B, and 100 in Group C. Mean age was 26.9± 6.6 years for Group A, 27.6± 7.3 years for Group B and 35.7± 9.2 years for Group C (p= 0.06). All subjects were females except for 1 male patient in Group A. Mean TMH, TMA and TMD in Group C were 487.7± 185.6 μm, 0.068± 0.040 mm2, and 341.2± 99.1 μm, respectively, which was significantly higher compared to Group A (225.5± 27.9 μm, 0.018± 0.004 mm2 and 171.9± 26.0 μm, respectively, all p < 0.001) and Group B (395.4± 118.8 μm, p < 0.001; 0.05± 0.04 mm2, p=0.016 and 280.6± 93.4 μm, p < 0.001, respectively). Group B eyes also had significantly higher parameters compared to Group A (all p < 0.001). Mean corneal and epithelial thickness in Group C were 501.6± 37.5 μm and 53.3± 4.5 μm, respectively, which was significantly higher compared to Group A (496.1± 24.1 μm, p=0.044 and 49.5± 3.5 μm, p < 0.001, respectively) and Group B (504.2± 22.03 μm, p=0.046 and 47.5± 5.6 μm, p < 0.001, respectively). Group B eyes also had a significantly higher corneal thickness (p=0.031) and epithelial thickness (p=0.011) compared to Group A.Conclusion: We demonstrated significant reduction of tear meniscus dimensions, central corneal thickness and epithelial thickness in SLE patients compared to age-matched controls using AS-OCT.Keywords: anterior segment optical coherence tomography, tear film, dry eye disease, systemic lupus erythematosusMahmoud MSEHamid MAAbdelkader MFDove Medical Pressarticleanterior segment optical coherence tomographytear filmdry eye diseasesystemic lupus erythematousOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3391-3399 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anterior segment optical coherence tomography tear film dry eye disease systemic lupus erythematous Ophthalmology RE1-994
spellingShingle	anterior segment optical coherence tomography tear film dry eye disease systemic lupus erythematous Ophthalmology RE1-994 Mahmoud MSE Hamid MA Abdelkader MF Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
description	Mohamed Salah El-Din Mahmoud, Mohamed A Hamid, Mohamed Farouk Abdelkader Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptEmail drmohamedhamid83@mu.edu.egPurpose: To study tear film and corneal thickness measurements in systemic lupus erythematosus (SLE) patients compared to age-matched controls using anterior segment optical coherence tomography (AS-OCT).Methods: This was a cross-sectional study. Study participants were divided into 3 groups: Group A: SLE patients with clinical dry eye, Group B: SLE patients without clinical dry eye and Group C: healthy controls. The lower tear meniscus parameters measured using AS-OCT were tear meniscus height (TMH), tear meniscus depth (TMD) and tear meniscus area (TMA). The central corneal and corneal epithelial thickness were automatically calculated.Results: The study included 40 eyes in Group A, 60 in Group B, and 100 in Group C. Mean age was 26.9± 6.6 years for Group A, 27.6± 7.3 years for Group B and 35.7± 9.2 years for Group C (p= 0.06). All subjects were females except for 1 male patient in Group A. Mean TMH, TMA and TMD in Group C were 487.7± 185.6 μm, 0.068± 0.040 mm2, and 341.2± 99.1 μm, respectively, which was significantly higher compared to Group A (225.5± 27.9 μm, 0.018± 0.004 mm2 and 171.9± 26.0 μm, respectively, all p < 0.001) and Group B (395.4± 118.8 μm, p < 0.001; 0.05± 0.04 mm2, p=0.016 and 280.6± 93.4 μm, p < 0.001, respectively). Group B eyes also had significantly higher parameters compared to Group A (all p < 0.001). Mean corneal and epithelial thickness in Group C were 501.6± 37.5 μm and 53.3± 4.5 μm, respectively, which was significantly higher compared to Group A (496.1± 24.1 μm, p=0.044 and 49.5± 3.5 μm, p < 0.001, respectively) and Group B (504.2± 22.03 μm, p=0.046 and 47.5± 5.6 μm, p < 0.001, respectively). Group B eyes also had a significantly higher corneal thickness (p=0.031) and epithelial thickness (p=0.011) compared to Group A.Conclusion: We demonstrated significant reduction of tear meniscus dimensions, central corneal thickness and epithelial thickness in SLE patients compared to age-matched controls using AS-OCT.Keywords: anterior segment optical coherence tomography, tear film, dry eye disease, systemic lupus erythematosus
format	article
author	Mahmoud MSE Hamid MA Abdelkader MF
author_facet	Mahmoud MSE Hamid MA Abdelkader MF
author_sort	Mahmoud MSE
title	Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
title_short	Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
title_full	Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
title_fullStr	Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
title_full_unstemmed	Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients
title_sort	anterior segment optical coherence tomography of tear film and cornea in systemic lupus erythematosus patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2efc7ef5da6441bcbde5467c5eed83eb
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Anterior Segment Optical Coherence Tomography of Tear Film and Cornea in Systemic Lupus Erythematosus Patients

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