Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential

Multimorbidity is the major cause of ill-health and premature death in developed countries. The ability to identify individuals at risk of developing chronic disease, particularly multimorbidity, reliably, and simply, and to identify undiagnosed disorders, is vital to reducing the global burden of d...

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Autores principales:	Karen N. Barnett, Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic disease data linkage faecal haemoglobin faecal immunochemical test inflammation multimorbidity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2f009fec1977418d8c71529dea97c166
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spelling	oai:doaj.org-article:2f009fec1977418d8c71529dea97c1662021-11-25T17:21:34ZFaecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential10.3390/diagnostics111120932075-4418https://doaj.org/article/2f009fec1977418d8c71529dea97c1662021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2093https://doaj.org/toc/2075-4418Multimorbidity is the major cause of ill-health and premature death in developed countries. The ability to identify individuals at risk of developing chronic disease, particularly multimorbidity, reliably, and simply, and to identify undiagnosed disorders, is vital to reducing the global burden of disease. This narrative review, the first of recent studies, demonstrates that raised faecal haemoglobin concentration (f-Hb) is associated with increased all-cause and cause-specific mortality and with longer-term conditions including diabetes, hypertension, cardiovascular disease, and psoriasis, and with probable intake of particulate matter. We and others have hypothesized that elevated f-Hb (measured using a faecal immunochemical test) has considerable potential to identify individuals at risk of, or who already have, early stage, undiagnosed chronic disease. If f-Hb does prove to be an effective biomarker for chronic disease and multimorbidity, individuals with detectable f-Hb, but without an obvious source of gastrointestinal blood loss, could benefit from further assessment and early intervention. To test this hypothesis rigorously, longitudinal data-linkage methodology is required linking colorectal cancer screening data, and data on patients presenting with lower gastrointestinal symptoms, with routinely collected health information.Karen N. BarnettGavin R. C. ClarkRobert J. C. SteeleCallum G. FraserMDPI AGarticlechronic diseasedata linkagefaecal haemoglobinfaecal immunochemical testinflammationmultimorbidityMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2093, p 2093 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic disease data linkage faecal haemoglobin faecal immunochemical test inflammation multimorbidity Medicine (General) R5-920
spellingShingle	chronic disease data linkage faecal haemoglobin faecal immunochemical test inflammation multimorbidity Medicine (General) R5-920 Karen N. Barnett Gavin R. C. Clark Robert J. C. Steele Callum G. Fraser Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
description	Multimorbidity is the major cause of ill-health and premature death in developed countries. The ability to identify individuals at risk of developing chronic disease, particularly multimorbidity, reliably, and simply, and to identify undiagnosed disorders, is vital to reducing the global burden of disease. This narrative review, the first of recent studies, demonstrates that raised faecal haemoglobin concentration (f-Hb) is associated with increased all-cause and cause-specific mortality and with longer-term conditions including diabetes, hypertension, cardiovascular disease, and psoriasis, and with probable intake of particulate matter. We and others have hypothesized that elevated f-Hb (measured using a faecal immunochemical test) has considerable potential to identify individuals at risk of, or who already have, early stage, undiagnosed chronic disease. If f-Hb does prove to be an effective biomarker for chronic disease and multimorbidity, individuals with detectable f-Hb, but without an obvious source of gastrointestinal blood loss, could benefit from further assessment and early intervention. To test this hypothesis rigorously, longitudinal data-linkage methodology is required linking colorectal cancer screening data, and data on patients presenting with lower gastrointestinal symptoms, with routinely collected health information.
format	article
author	Karen N. Barnett Gavin R. C. Clark Robert J. C. Steele Callum G. Fraser
author_facet	Karen N. Barnett Gavin R. C. Clark Robert J. C. Steele Callum G. Fraser
author_sort	Karen N. Barnett
title	Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
title_short	Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
title_full	Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
title_fullStr	Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
title_full_unstemmed	Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential
title_sort	faecal haemoglobin estimated by faecal immunochemical tests—an indicator of systemic inflammation with real clinical potential
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2f009fec1977418d8c71529dea97c166
work_keys_str_mv	AT karennbarnett faecalhaemoglobinestimatedbyfaecalimmunochemicaltestsanindicatorofsystemicinflammationwithrealclinicalpotential AT gavinrcclark faecalhaemoglobinestimatedbyfaecalimmunochemicaltestsanindicatorofsystemicinflammationwithrealclinicalpotential AT robertjcsteele faecalhaemoglobinestimatedbyfaecalimmunochemicaltestsanindicatorofsystemicinflammationwithrealclinicalpotential AT callumgfraser faecalhaemoglobinestimatedbyfaecalimmunochemicaltestsanindicatorofsystemicinflammationwithrealclinicalpotential
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Faecal Haemoglobin Estimated by Faecal Immunochemical Tests—An Indicator of Systemic Inflammation with Real Clinical Potential

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