In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to...

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Autores principales:	Sivanandane Sittadjody, Justin M. Saul, John P. McQuilling, Sunyoung Joo, Thomas C. Register, James J. Yoo, Anthony Atala, Emmanuel C. Opara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f00be5ec136452597716fa09f07aa1d
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spelling	oai:doaj.org-article:2f00be5ec136452597716fa09f07aa1d2021-12-02T15:38:49ZIn vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure10.1038/s41467-017-01851-32041-1723https://doaj.org/article/2f00be5ec136452597716fa09f07aa1d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01851-3https://doaj.org/toc/2041-1723Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to similar doses of pHRT.Sivanandane SittadjodyJustin M. SaulJohn P. McQuillingSunyoung JooThomas C. RegisterJames J. YooAnthony AtalaEmmanuel C. OparaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sivanandane Sittadjody Justin M. Saul John P. McQuilling Sunyoung Joo Thomas C. Register James J. Yoo Anthony Atala Emmanuel C. Opara In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
description	Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to similar doses of pHRT.
format	article
author	Sivanandane Sittadjody Justin M. Saul John P. McQuilling Sunyoung Joo Thomas C. Register James J. Yoo Anthony Atala Emmanuel C. Opara
author_facet	Sivanandane Sittadjody Justin M. Saul John P. McQuilling Sunyoung Joo Thomas C. Register James J. Yoo Anthony Atala Emmanuel C. Opara
author_sort	Sivanandane Sittadjody
title	In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
title_short	In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
title_full	In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
title_fullStr	In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
title_full_unstemmed	In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
title_sort	in vivo transplantation of 3d encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f00be5ec136452597716fa09f07aa1d
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In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

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