In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to...

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Autores principales: Sivanandane Sittadjody, Justin M. Saul, John P. McQuilling, Sunyoung Joo, Thomas C. Register, James J. Yoo, Anthony Atala, Emmanuel C. Opara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/2f00be5ec136452597716fa09f07aa1d
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