In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to...

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Bibliographic Details
Main Authors: Sivanandane Sittadjody, Justin M. Saul, John P. McQuilling, Sunyoung Joo, Thomas C. Register, James J. Yoo, Anthony Atala, Emmanuel C. Opara
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
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Online Access:https://doaj.org/article/2f00be5ec136452597716fa09f07aa1d
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