Changes in vitamin D levels and depressive symptoms in later life in England

Abstract Inadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hyd...

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Autores principales:	Giorgio Di Gessa, Jane P. Biddulph, Paola Zaninotto, Cesar de Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f046c8e6b3b4424af7ca756f9551613
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spelling	oai:doaj.org-article:2f046c8e6b3b4424af7ca756f95516132021-12-02T14:15:53ZChanges in vitamin D levels and depressive symptoms in later life in England10.1038/s41598-021-87432-32045-2322https://doaj.org/article/2f046c8e6b3b4424af7ca756f95516132021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87432-3https://doaj.org/toc/2045-2322Abstract Inadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient < 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels < 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms.Giorgio Di GessaJane P. BiddulphPaola ZaninottoCesar de OliveiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giorgio Di Gessa Jane P. Biddulph Paola Zaninotto Cesar de Oliveira Changes in vitamin D levels and depressive symptoms in later life in England
description	Abstract Inadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient < 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels < 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms.
format	article
author	Giorgio Di Gessa Jane P. Biddulph Paola Zaninotto Cesar de Oliveira
author_facet	Giorgio Di Gessa Jane P. Biddulph Paola Zaninotto Cesar de Oliveira
author_sort	Giorgio Di Gessa
title	Changes in vitamin D levels and depressive symptoms in later life in England
title_short	Changes in vitamin D levels and depressive symptoms in later life in England
title_full	Changes in vitamin D levels and depressive symptoms in later life in England
title_fullStr	Changes in vitamin D levels and depressive symptoms in later life in England
title_full_unstemmed	Changes in vitamin D levels and depressive symptoms in later life in England
title_sort	changes in vitamin d levels and depressive symptoms in later life in england
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f046c8e6b3b4424af7ca756f9551613
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Changes in vitamin D levels and depressive symptoms in later life in England

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