Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients

Abstract Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurr...

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Autores principales:	Fei-Yan Xiao, Jian-Quan Luo, Min Liu, Bi-Lian Chen, Shan Cao, Zhao-Qian Liu, Hong-Hao Zhou, Gan Zhou, Wei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f0529fa67884af39b5ca50b417bbf92
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spelling	oai:doaj.org-article:2f0529fa67884af39b5ca50b417bbf922021-12-02T16:06:01ZEffect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients10.1038/s41598-017-07736-12045-2322https://doaj.org/article/2f0529fa67884af39b5ca50b417bbf922017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07736-1https://doaj.org/toc/2045-2322Abstract Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT + TT group for cerebrovascular events (14% vs 4.8%, p < 0.001, OR = 0.31), acute myocardial infarction (15.1% vs 6.1%, p < 0.001, OR = 0.37) and unstable angina (62.8% vs 37.7%, p < 0.001, OR = 0.36). The results showed that there was a significant association between CES1 S75N (rs2307240) and the outcome of clopidogrel therapy. Moreover, the frequency of the T allele of rs2307240 in acute coronary syndrome patients (MAF = 0.22) was more than four times higher than that in the general public (MAF = 0.05).Fei-Yan XiaoJian-Quan LuoMin LiuBi-Lian ChenShan CaoZhao-Qian LiuHong-Hao ZhouGan ZhouWei ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei-Yan Xiao Jian-Quan Luo Min Liu Bi-Lian Chen Shan Cao Zhao-Qian Liu Hong-Hao Zhou Gan Zhou Wei Zhang Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
description	Abstract Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT + TT group for cerebrovascular events (14% vs 4.8%, p < 0.001, OR = 0.31), acute myocardial infarction (15.1% vs 6.1%, p < 0.001, OR = 0.37) and unstable angina (62.8% vs 37.7%, p < 0.001, OR = 0.36). The results showed that there was a significant association between CES1 S75N (rs2307240) and the outcome of clopidogrel therapy. Moreover, the frequency of the T allele of rs2307240 in acute coronary syndrome patients (MAF = 0.22) was more than four times higher than that in the general public (MAF = 0.05).
format	article
author	Fei-Yan Xiao Jian-Quan Luo Min Liu Bi-Lian Chen Shan Cao Zhao-Qian Liu Hong-Hao Zhou Gan Zhou Wei Zhang
author_facet	Fei-Yan Xiao Jian-Quan Luo Min Liu Bi-Lian Chen Shan Cao Zhao-Qian Liu Hong-Hao Zhou Gan Zhou Wei Zhang
author_sort	Fei-Yan Xiao
title	Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
title_short	Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
title_full	Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
title_fullStr	Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
title_full_unstemmed	Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
title_sort	effect of carboxylesterase 1 s75n on clopidogrel therapy among acute coronary syndrome patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f0529fa67884af39b5ca50b417bbf92
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Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients

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