Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2

Risk for the paediatric cancer high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) has been associated with genetic variants at 10q21.2. Here, the authors characterize this region, establishing a single risk variant and showing its role in dysregulated expression ofARID5B.

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Autores principales:	James B. Studd, Jayaram Vijayakrishnan, Minjun Yang, Gabriele Migliorini, Kajsa Paulsson, Richard S. Houlston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f05a5509ae64698a25e08892abeb315
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spelling	oai:doaj.org-article:2f05a5509ae64698a25e08892abeb3152021-12-02T14:42:45ZGenetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.210.1038/ncomms146162041-1723https://doaj.org/article/2f05a5509ae64698a25e08892abeb3152017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14616https://doaj.org/toc/2041-1723Risk for the paediatric cancer high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) has been associated with genetic variants at 10q21.2. Here, the authors characterize this region, establishing a single risk variant and showing its role in dysregulated expression ofARID5B.James B. StuddJayaram VijayakrishnanMinjun YangGabriele MiglioriniKajsa PaulssonRichard S. HoulstonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James B. Studd Jayaram Vijayakrishnan Minjun Yang Gabriele Migliorini Kajsa Paulsson Richard S. Houlston Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
description	Risk for the paediatric cancer high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) has been associated with genetic variants at 10q21.2. Here, the authors characterize this region, establishing a single risk variant and showing its role in dysregulated expression ofARID5B.
format	article
author	James B. Studd Jayaram Vijayakrishnan Minjun Yang Gabriele Migliorini Kajsa Paulsson Richard S. Houlston
author_facet	James B. Studd Jayaram Vijayakrishnan Minjun Yang Gabriele Migliorini Kajsa Paulsson Richard S. Houlston
author_sort	James B. Studd
title	Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
title_short	Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
title_full	Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
title_fullStr	Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
title_full_unstemmed	Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
title_sort	genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f05a5509ae64698a25e08892abeb315
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Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2

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