Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein

Proteins play an important role in biological and biochemical processes taking place in the living system. To uncover these fundamental processes of the living system, it is an absolutely necessary task to understand the structure and dynamics of the protein. Vibrational spectroscopy is an establish...

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Autor principal:	Kiran Sankar Maiti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vibrational spectroscopy VSCF pair potential one-dimensional IR two-dimensional IR dual frequency Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/2f082ee83fa14e93a8d066433fae4ca6
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id	oai:doaj.org-article:2f082ee83fa14e93a8d066433fae4ca6
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spelling	oai:doaj.org-article:2f082ee83fa14e93a8d066433fae4ca62021-11-25T18:28:10ZTwo-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein10.3390/molecules262268931420-3049https://doaj.org/article/2f082ee83fa14e93a8d066433fae4ca62021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6893https://doaj.org/toc/1420-3049Proteins play an important role in biological and biochemical processes taking place in the living system. To uncover these fundamental processes of the living system, it is an absolutely necessary task to understand the structure and dynamics of the protein. Vibrational spectroscopy is an established tool to explore protein structure and dynamics. In particular, two-dimensional infrared (2DIR) spectroscopy has already proven its versatility to explore the protein structure and its ultrafast dynamics, and it has essentially unprecedented time resolutions to observe the vibrational dynamics of the protein. Providing several examples from our theoretical and experimental efforts, it is established here that two-dimensional vibrational spectroscopy provides exceptionally more information than one-dimensional vibrational spectroscopy. The structural information of the protein is encoded in the position, shape, and strength of the peak in 2DIR spectra. The time evolution of the 2DIR spectra allows for the visualisation of molecular motions.Kiran Sankar MaitiMDPI AGarticlevibrational spectroscopyVSCFpair potentialone-dimensional IRtwo-dimensional IRdual frequencyOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6893, p 6893 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vibrational spectroscopy VSCF pair potential one-dimensional IR two-dimensional IR dual frequency Organic chemistry QD241-441
spellingShingle	vibrational spectroscopy VSCF pair potential one-dimensional IR two-dimensional IR dual frequency Organic chemistry QD241-441 Kiran Sankar Maiti Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
description	Proteins play an important role in biological and biochemical processes taking place in the living system. To uncover these fundamental processes of the living system, it is an absolutely necessary task to understand the structure and dynamics of the protein. Vibrational spectroscopy is an established tool to explore protein structure and dynamics. In particular, two-dimensional infrared (2DIR) spectroscopy has already proven its versatility to explore the protein structure and its ultrafast dynamics, and it has essentially unprecedented time resolutions to observe the vibrational dynamics of the protein. Providing several examples from our theoretical and experimental efforts, it is established here that two-dimensional vibrational spectroscopy provides exceptionally more information than one-dimensional vibrational spectroscopy. The structural information of the protein is encoded in the position, shape, and strength of the peak in 2DIR spectra. The time evolution of the 2DIR spectra allows for the visualisation of molecular motions.
format	article
author	Kiran Sankar Maiti
author_facet	Kiran Sankar Maiti
author_sort	Kiran Sankar Maiti
title	Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
title_short	Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
title_full	Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
title_fullStr	Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
title_full_unstemmed	Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein
title_sort	two-dimensional infrared spectroscopy reveals better insights of structure and dynamics of protein
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2f082ee83fa14e93a8d066433fae4ca6
work_keys_str_mv	AT kiransankarmaiti twodimensionalinfraredspectroscopyrevealsbetterinsightsofstructureanddynamicsofprotein
_version_	1718411124612792320

Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein

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