Chemical Exposures Affect Innate Immune Response to SARS-CoV-2

Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that an interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olatunbosun Arowolo, Leonid Pobezinsky, Alexander Suvorov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 in silico toxicity xenobiotics IFN signaling Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2f0e1a7026c94f5ab3ff551ced54d517
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f0e1a7026c94f5ab3ff551ced54d517
record_format	dspace
spelling	oai:doaj.org-article:2f0e1a7026c94f5ab3ff551ced54d5172021-11-25T17:56:59ZChemical Exposures Affect Innate Immune Response to SARS-CoV-210.3390/ijms2222124741422-00671661-6596https://doaj.org/article/2f0e1a7026c94f5ab3ff551ced54d5172021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12474https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that an interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly exposed populations. Therefore, a better understanding of the molecular basis of the interaction between SARS-CoV-2 infection and chemical exposures may open opportunities for better preventive and therapeutic interventions. We attempted to gain mechanistic knowledge on the interaction between SARS-CoV-2 infection and chemical exposures using an in silico approach, where we identified genes and molecular pathways affected by both chemical exposures and SARS-CoV-2 in human immune cells (T-cells, B-cells, NK-cells, dendritic, and monocyte cells). Our findings demonstrate for the first time that overlapping molecular mechanisms affected by a broad range of chemical exposures and COVID-19 are linked to IFN type I/II signaling pathways and the process of antigen presentation. Based on our data, we also predict that exposures to various chemical compounds will predominantly impact the population of monocytes during the response against COVID-19.Olatunbosun ArowoloLeonid PobezinskyAlexander SuvorovMDPI AGarticleCOVID-19SARS-CoV-2in silicotoxicityxenobioticsIFN signalingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12474, p 12474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 in silico toxicity xenobiotics IFN signaling Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	COVID-19 SARS-CoV-2 in silico toxicity xenobiotics IFN signaling Biology (General) QH301-705.5 Chemistry QD1-999 Olatunbosun Arowolo Leonid Pobezinsky Alexander Suvorov Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
description	Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that an interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly exposed populations. Therefore, a better understanding of the molecular basis of the interaction between SARS-CoV-2 infection and chemical exposures may open opportunities for better preventive and therapeutic interventions. We attempted to gain mechanistic knowledge on the interaction between SARS-CoV-2 infection and chemical exposures using an in silico approach, where we identified genes and molecular pathways affected by both chemical exposures and SARS-CoV-2 in human immune cells (T-cells, B-cells, NK-cells, dendritic, and monocyte cells). Our findings demonstrate for the first time that overlapping molecular mechanisms affected by a broad range of chemical exposures and COVID-19 are linked to IFN type I/II signaling pathways and the process of antigen presentation. Based on our data, we also predict that exposures to various chemical compounds will predominantly impact the population of monocytes during the response against COVID-19.
format	article
author	Olatunbosun Arowolo Leonid Pobezinsky Alexander Suvorov
author_facet	Olatunbosun Arowolo Leonid Pobezinsky Alexander Suvorov
author_sort	Olatunbosun Arowolo
title	Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
title_short	Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
title_full	Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
title_fullStr	Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
title_full_unstemmed	Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
title_sort	chemical exposures affect innate immune response to sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2f0e1a7026c94f5ab3ff551ced54d517
work_keys_str_mv	AT olatunbosunarowolo chemicalexposuresaffectinnateimmuneresponsetosarscov2 AT leonidpobezinsky chemicalexposuresaffectinnateimmuneresponsetosarscov2 AT alexandersuvorov chemicalexposuresaffectinnateimmuneresponsetosarscov2
_version_	1718411792388980736

Chemical Exposures Affect Innate Immune Response to SARS-CoV-2

Ejemplares similares