Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma

Background and Aim: Placental Growth Factor (PlGF) plays a crucial role in angiogenesis and was identified as a potential prognostic biomarker in various types of cancer. Therefore, we evaluated the diagnostic accuracy and prognostic value of PlGF serum concentration in patients with clear cell rena...

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Autores principales:	Marcela Cechova, Matus Chocholaty, Marek Babjuk, Tomas Zima, Klara Havlova, Marketa Koldova, Marek Schmidt, Marta Kalousova
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	placental growth factor plgf clear cell renal cell carcinoma biomarker diagnosis prognosis Medicine R
Acceso en línea:	https://doaj.org/article/2f0e69117d8a4b63859c4fc8180da4e3
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spelling	oai:doaj.org-article:2f0e69117d8a4b63859c4fc8180da4e32021-11-29T09:17:21ZDiagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma1213-81181804-7521https://doaj.org/article/2f0e69117d8a4b63859c4fc8180da4e32021-11-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202104-0004_diagnostic-and-prognostic-value-of-placental-growth-factor-serum-concentration-in-clear-cell-renal-cell-carcino.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background and Aim: Placental Growth Factor (PlGF) plays a crucial role in angiogenesis and was identified as a potential prognostic biomarker in various types of cancer. Therefore, we evaluated the diagnostic accuracy and prognostic value of PlGF serum concentration in patients with clear cell renal cell carcinoma (ccRCC). Patients and Methods: A total of 49 patients subjected to partial or radical nephrectomy for ccRCC [localized without relapse (lccRCC; n=31), localized with later relapse (rccRCC; n=8), primary metastatic cancer (mccRCC; n=10); median of follow-up 4.4 years] were enrolled in a prospective study to assess the significance of PlGF serum concentration. PlGF was measured prior to surgery and 3 months postoperatively. Our control group consisted of 38 healthy subjects. Results: PlGF serum concentration was significantly higher in ccRCC compared to controls (P=0.002). The cut-off value of PlGF concentration for the risk of ccRCC was determined at 12.71 pg/mL (AUC=0.729; P=0.0001). Prior to surgery, among ccRCC subgroups, significantly higher PlGF concentration was detected in mccRCC compared to lccRCC (P=0.002). Postoperatively, we observed a tendency to higher PlGF serum concentration in rccRCC compared to lccRCC subgroup, however without significance (P=0.17). The cut-off value for the risk of relapse was 11.41 pg/mL (AUC=0.792; P=0.0003). In subjects with localized ccRCC with PlGF concentration below 11.41 pg/mL 3-years cancer specific survival was 93% compared to 61% in subject with concentration above the cut-off value (P=0.018). Conclusion: Based on our findings, PlGF serum concentration seems to be a useful biomarker in diagnostics and prediction of prognosis in ccRCC.Marcela CechovaMatus ChocholatyMarek BabjukTomas ZimaKlara HavlovaMarketa KoldovaMarek SchmidtMarta KalousovaPalacký University Olomouc, Faculty of Medicine and Dentistryarticleplacental growth factorplgfclear cell renal cell carcinomabiomarkerdiagnosisprognosisMedicineRENBiomedical Papers, Vol 165, Iss 4, Pp 375-379 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	placental growth factor plgf clear cell renal cell carcinoma biomarker diagnosis prognosis Medicine R
spellingShingle	placental growth factor plgf clear cell renal cell carcinoma biomarker diagnosis prognosis Medicine R Marcela Cechova Matus Chocholaty Marek Babjuk Tomas Zima Klara Havlova Marketa Koldova Marek Schmidt Marta Kalousova Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
description	Background and Aim: Placental Growth Factor (PlGF) plays a crucial role in angiogenesis and was identified as a potential prognostic biomarker in various types of cancer. Therefore, we evaluated the diagnostic accuracy and prognostic value of PlGF serum concentration in patients with clear cell renal cell carcinoma (ccRCC). Patients and Methods: A total of 49 patients subjected to partial or radical nephrectomy for ccRCC [localized without relapse (lccRCC; n=31), localized with later relapse (rccRCC; n=8), primary metastatic cancer (mccRCC; n=10); median of follow-up 4.4 years] were enrolled in a prospective study to assess the significance of PlGF serum concentration. PlGF was measured prior to surgery and 3 months postoperatively. Our control group consisted of 38 healthy subjects. Results: PlGF serum concentration was significantly higher in ccRCC compared to controls (P=0.002). The cut-off value of PlGF concentration for the risk of ccRCC was determined at 12.71 pg/mL (AUC=0.729; P=0.0001). Prior to surgery, among ccRCC subgroups, significantly higher PlGF concentration was detected in mccRCC compared to lccRCC (P=0.002). Postoperatively, we observed a tendency to higher PlGF serum concentration in rccRCC compared to lccRCC subgroup, however without significance (P=0.17). The cut-off value for the risk of relapse was 11.41 pg/mL (AUC=0.792; P=0.0003). In subjects with localized ccRCC with PlGF concentration below 11.41 pg/mL 3-years cancer specific survival was 93% compared to 61% in subject with concentration above the cut-off value (P=0.018). Conclusion: Based on our findings, PlGF serum concentration seems to be a useful biomarker in diagnostics and prediction of prognosis in ccRCC.
format	article
author	Marcela Cechova Matus Chocholaty Marek Babjuk Tomas Zima Klara Havlova Marketa Koldova Marek Schmidt Marta Kalousova
author_facet	Marcela Cechova Matus Chocholaty Marek Babjuk Tomas Zima Klara Havlova Marketa Koldova Marek Schmidt Marta Kalousova
author_sort	Marcela Cechova
title	Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
title_short	Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
title_full	Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
title_fullStr	Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
title_full_unstemmed	Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
title_sort	diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/2f0e69117d8a4b63859c4fc8180da4e3
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_version_	1718407393333739520

Diagnostic and prognostic value of placental growth factor serum concentration in clear cell renal cell carcinoma

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