Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study

Abstract In the current study, we investigated the amplitude of low frequency fluctuations (ALFF) at rest and during a rumination induction. Specifically, we explored the differences of cortical blood oxygenation using fNIRS in subjects with Major Depressive Disorder (MDD) and healthy controls (HC)....

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Autores principales:	David Rosenbaum, Isabell Int-Veen, Agnes Kroczek, Paula Hilsendegen, Kerstin Velten-Schurian, Isabel Bihlmaier, Andreas J. Fallgatter, Ann-Christine Ehlis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f0ea90113d34e369204d57d27ed853b
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spelling	oai:doaj.org-article:2f0ea90113d34e369204d57d27ed853b2021-12-02T16:18:04ZAmplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study10.1038/s41598-020-78317-y2045-2322https://doaj.org/article/2f0ea90113d34e369204d57d27ed853b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78317-yhttps://doaj.org/toc/2045-2322Abstract In the current study, we investigated the amplitude of low frequency fluctuations (ALFF) at rest and during a rumination induction. Specifically, we explored the differences of cortical blood oxygenation using fNIRS in subjects with Major Depressive Disorder (MDD) and healthy controls (HC). Rumination was assessed as state and trait measure, as well as with a qualitative semi-structured interview. Qualitative and quantitative measures of rumination indicated that the MDD group showed elevated rumination regarding state and trait measures. Furthermore, rumination differed qualitatively between the groups. The MDD group showed higher levels of general rumination and increased rumination during the rumination induction. However, the MDD group did not show a carry-over effect of elevated rumination after the induction paradigm to the following resting-state measurement. On a neuronal level, we observed a general hypoactivity in the MDD group compared to the HC group. Moreover, both groups showed increased ALFF during the rumination induction compared to the rest phase, especially in temporo-parietal areas. However, no interaction effect of MDD status and rumination induction was found. The current findings are discussed with respect to the literature of paradigms used in the investigation of rumination and suggestions on general improvements in rumination research are given.David RosenbaumIsabell Int-VeenAgnes KroczekPaula HilsendegenKerstin Velten-SchurianIsabel BihlmaierAndreas J. FallgatterAnn-Christine EhlisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Rosenbaum Isabell Int-Veen Agnes Kroczek Paula Hilsendegen Kerstin Velten-Schurian Isabel Bihlmaier Andreas J. Fallgatter Ann-Christine Ehlis Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
description	Abstract In the current study, we investigated the amplitude of low frequency fluctuations (ALFF) at rest and during a rumination induction. Specifically, we explored the differences of cortical blood oxygenation using fNIRS in subjects with Major Depressive Disorder (MDD) and healthy controls (HC). Rumination was assessed as state and trait measure, as well as with a qualitative semi-structured interview. Qualitative and quantitative measures of rumination indicated that the MDD group showed elevated rumination regarding state and trait measures. Furthermore, rumination differed qualitatively between the groups. The MDD group showed higher levels of general rumination and increased rumination during the rumination induction. However, the MDD group did not show a carry-over effect of elevated rumination after the induction paradigm to the following resting-state measurement. On a neuronal level, we observed a general hypoactivity in the MDD group compared to the HC group. Moreover, both groups showed increased ALFF during the rumination induction compared to the rest phase, especially in temporo-parietal areas. However, no interaction effect of MDD status and rumination induction was found. The current findings are discussed with respect to the literature of paradigms used in the investigation of rumination and suggestions on general improvements in rumination research are given.
format	article
author	David Rosenbaum Isabell Int-Veen Agnes Kroczek Paula Hilsendegen Kerstin Velten-Schurian Isabel Bihlmaier Andreas J. Fallgatter Ann-Christine Ehlis
author_facet	David Rosenbaum Isabell Int-Veen Agnes Kroczek Paula Hilsendegen Kerstin Velten-Schurian Isabel Bihlmaier Andreas J. Fallgatter Ann-Christine Ehlis
author_sort	David Rosenbaum
title	Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
title_short	Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
title_full	Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
title_fullStr	Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
title_full_unstemmed	Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study
title_sort	amplitude of low frequency fluctuations (alff) of spontaneous and induced rumination in major depression: an fnirs study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2f0ea90113d34e369204d57d27ed853b
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Amplitude of low frequency fluctuations (ALFF) of spontaneous and induced rumination in major depression: An fNIRS study

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