The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance

Abstract The arginine metabolism as a target for cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI) remains insufficiently understood. Arginine, ornithine, citrulline, asymmetric dimethylarginine (ADMA) and proline plasma levels were measured using liquid chromatogr...

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Autores principales:	Patrycja Molek, Pawel Zmudzki, Aleksandra Wlodarczyk, Jadwiga Nessler, Jaroslaw Zalewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f149b97755a40159eac15f7ee633ec4
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spelling	oai:doaj.org-article:2f149b97755a40159eac15f7ee633ec42021-12-02T15:12:55ZThe shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance10.1038/s41598-020-80230-32045-2322https://doaj.org/article/2f149b97755a40159eac15f7ee633ec42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80230-3https://doaj.org/toc/2045-2322Abstract The arginine metabolism as a target for cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI) remains insufficiently understood. Arginine, ornithine, citrulline, asymmetric dimethylarginine (ADMA) and proline plasma levels were measured using liquid chromatography and tandem mass spectrometry in 70 consecutive STEMI patients upon admission and at 6-month follow-up and were compared with left ventricular function, volumes, and infarct characteristics determined by cardiac magnetic resonance imaging, and with 5-year clinical outcomes. Baseline median concentration of arginine was higher by 49% (P = 0.002) when compared to 6-month measurements and was correlated with an ischemia risk area (R = 0.34, P = 0.004) and infarct size (R = 0.33, P = 0.006). Following ischemia median citrulline/arginine index decreased when compared with 6-month result (P = 0.002), while citrulline/ornithine and arginine/ADMA ratios maintained unchanged indicating a shift of arginine metabolism from nitric oxide synthase (NOS) towards arginase. The 6-month arginine concentration reached the area under the ROC curve of 0.67 (95% confidence interval 0.54–0.81) for prediction of death, myocardial infarction or heart failure hospitalization and its value of < 29 µM was associated with lower event free survival (P = 0.02). In STEMI patients, during ischemia conversion of elevated plasma arginine was shifted from NOS towards arginase. Decreased 6-month arginine concentrations were associated with worse long-term outcomes.Patrycja MolekPawel ZmudzkiAleksandra WlodarczykJadwiga NesslerJaroslaw ZalewskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrycja Molek Pawel Zmudzki Aleksandra Wlodarczyk Jadwiga Nessler Jaroslaw Zalewski The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
description	Abstract The arginine metabolism as a target for cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI) remains insufficiently understood. Arginine, ornithine, citrulline, asymmetric dimethylarginine (ADMA) and proline plasma levels were measured using liquid chromatography and tandem mass spectrometry in 70 consecutive STEMI patients upon admission and at 6-month follow-up and were compared with left ventricular function, volumes, and infarct characteristics determined by cardiac magnetic resonance imaging, and with 5-year clinical outcomes. Baseline median concentration of arginine was higher by 49% (P = 0.002) when compared to 6-month measurements and was correlated with an ischemia risk area (R = 0.34, P = 0.004) and infarct size (R = 0.33, P = 0.006). Following ischemia median citrulline/arginine index decreased when compared with 6-month result (P = 0.002), while citrulline/ornithine and arginine/ADMA ratios maintained unchanged indicating a shift of arginine metabolism from nitric oxide synthase (NOS) towards arginase. The 6-month arginine concentration reached the area under the ROC curve of 0.67 (95% confidence interval 0.54–0.81) for prediction of death, myocardial infarction or heart failure hospitalization and its value of < 29 µM was associated with lower event free survival (P = 0.02). In STEMI patients, during ischemia conversion of elevated plasma arginine was shifted from NOS towards arginase. Decreased 6-month arginine concentrations were associated with worse long-term outcomes.
format	article
author	Patrycja Molek Pawel Zmudzki Aleksandra Wlodarczyk Jadwiga Nessler Jaroslaw Zalewski
author_facet	Patrycja Molek Pawel Zmudzki Aleksandra Wlodarczyk Jadwiga Nessler Jaroslaw Zalewski
author_sort	Patrycja Molek
title	The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
title_short	The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
title_full	The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
title_fullStr	The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
title_full_unstemmed	The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
title_sort	shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f149b97755a40159eac15f7ee633ec4
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The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance

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