Targeting Hypoxia: Revival of Old Remedies

Tumour hypoxia is significantly correlated with patient survival and treatment outcomes. At the molecular level, hypoxia is a major driving factor for tumour progression and aggressiveness. Despite the accumulative scientific and clinical efforts to target hypoxia, there is still a need to find spec...

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Autores principales:	Nuria Vilaplana-Lopera, Maxym Besh, Eui Jung Moon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypoxia cancer tirapazamine hyperthermia carbogen breathing tumour metabolism Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2f1a5fafb1e94ff4b5dcacc6df687a95
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spelling	oai:doaj.org-article:2f1a5fafb1e94ff4b5dcacc6df687a952021-11-25T16:52:43ZTargeting Hypoxia: Revival of Old Remedies10.3390/biom111116042218-273Xhttps://doaj.org/article/2f1a5fafb1e94ff4b5dcacc6df687a952021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1604https://doaj.org/toc/2218-273XTumour hypoxia is significantly correlated with patient survival and treatment outcomes. At the molecular level, hypoxia is a major driving factor for tumour progression and aggressiveness. Despite the accumulative scientific and clinical efforts to target hypoxia, there is still a need to find specific treatments for tumour hypoxia. In this review, we discuss a variety of approaches to alter the low oxygen tumour microenvironment or hypoxia pathways including carbogen breathing, hyperthermia, hypoxia-activated prodrugs, tumour metabolism and hypoxia-inducible factor (HIF) inhibitors. The recent advances in technology and biological understanding reveal the importance of revisiting old therapeutic regimens and repurposing their uses clinically.Nuria Vilaplana-LoperaMaxym BeshEui Jung MoonMDPI AGarticlehypoxiacancertirapazaminehyperthermiacarbogen breathingtumour metabolismMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1604, p 1604 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxia cancer tirapazamine hyperthermia carbogen breathing tumour metabolism Microbiology QR1-502
spellingShingle	hypoxia cancer tirapazamine hyperthermia carbogen breathing tumour metabolism Microbiology QR1-502 Nuria Vilaplana-Lopera Maxym Besh Eui Jung Moon Targeting Hypoxia: Revival of Old Remedies
description	Tumour hypoxia is significantly correlated with patient survival and treatment outcomes. At the molecular level, hypoxia is a major driving factor for tumour progression and aggressiveness. Despite the accumulative scientific and clinical efforts to target hypoxia, there is still a need to find specific treatments for tumour hypoxia. In this review, we discuss a variety of approaches to alter the low oxygen tumour microenvironment or hypoxia pathways including carbogen breathing, hyperthermia, hypoxia-activated prodrugs, tumour metabolism and hypoxia-inducible factor (HIF) inhibitors. The recent advances in technology and biological understanding reveal the importance of revisiting old therapeutic regimens and repurposing their uses clinically.
format	article
author	Nuria Vilaplana-Lopera Maxym Besh Eui Jung Moon
author_facet	Nuria Vilaplana-Lopera Maxym Besh Eui Jung Moon
author_sort	Nuria Vilaplana-Lopera
title	Targeting Hypoxia: Revival of Old Remedies
title_short	Targeting Hypoxia: Revival of Old Remedies
title_full	Targeting Hypoxia: Revival of Old Remedies
title_fullStr	Targeting Hypoxia: Revival of Old Remedies
title_full_unstemmed	Targeting Hypoxia: Revival of Old Remedies
title_sort	targeting hypoxia: revival of old remedies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2f1a5fafb1e94ff4b5dcacc6df687a95
work_keys_str_mv	AT nuriavilaplanalopera targetinghypoxiarevivalofoldremedies AT maxymbesh targetinghypoxiarevivalofoldremedies AT euijungmoon targetinghypoxiarevivalofoldremedies
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Targeting Hypoxia: Revival of Old Remedies

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