Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and...

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Autores principales: Grigoriy A. Armeev, Anastasiia S. Kniazeva, Galina A. Komarova, Mikhail P. Kirpichnikov, Alexey K. Shaytan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2f1e4c2fcfc146acb72bcb475cf9ee2e
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Sumario:Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and plasticity enable DNA unwrapping and sliding.