Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and...

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Autores principales:	Grigoriy A. Armeev, Anastasiia S. Kniazeva, Galina A. Komarova, Mikhail P. Kirpichnikov, Alexey K. Shaytan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f1e4c2fcfc146acb72bcb475cf9ee2e
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spelling	oai:doaj.org-article:2f1e4c2fcfc146acb72bcb475cf9ee2e2021-12-02T17:33:34ZHistone dynamics mediate DNA unwrapping and sliding in nucleosomes10.1038/s41467-021-22636-92041-1723https://doaj.org/article/2f1e4c2fcfc146acb72bcb475cf9ee2e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22636-9https://doaj.org/toc/2041-1723Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and plasticity enable DNA unwrapping and sliding.Grigoriy A. ArmeevAnastasiia S. KniazevaGalina A. KomarovaMikhail P. KirpichnikovAlexey K. ShaytanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grigoriy A. Armeev Anastasiia S. Kniazeva Galina A. Komarova Mikhail P. Kirpichnikov Alexey K. Shaytan Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
description	Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and plasticity enable DNA unwrapping and sliding.
format	article
author	Grigoriy A. Armeev Anastasiia S. Kniazeva Galina A. Komarova Mikhail P. Kirpichnikov Alexey K. Shaytan
author_facet	Grigoriy A. Armeev Anastasiia S. Kniazeva Galina A. Komarova Mikhail P. Kirpichnikov Alexey K. Shaytan
author_sort	Grigoriy A. Armeev
title	Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
title_short	Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
title_full	Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
title_fullStr	Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
title_full_unstemmed	Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
title_sort	histone dynamics mediate dna unwrapping and sliding in nucleosomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f1e4c2fcfc146acb72bcb475cf9ee2e
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_version_	1718379932120252416

Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

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