Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

Abstract We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secret...

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Autores principales:	Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2f212191b8044471a09de9b169fd03d0
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spelling	oai:doaj.org-article:2f212191b8044471a09de9b169fd03d02021-12-02T15:51:11ZMeta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans10.1038/s41541-021-00305-82059-0105https://doaj.org/article/2f212191b8044471a09de9b169fd03d02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00305-8https://doaj.org/toc/2059-0105Abstract We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG.Kelly E. SeatonAaron DealXue HanShuying S. LiAshley ClaytonJack HeptinstallAnn DuerrMary A. AllenXiaoying ShenSheetal SawantNicole L. YatesPaul SpearmanGavin ChurchyardPaul A. GoepfertJanine MaenzaGlenda GrayGiuseppe PantaleoLaura PolakowskiHarriet L. RobinsonShannon GrantApril K. RandhawaYing HuangCecilia MorganNicole GrunenbergShelly KarunaPeter B. GilbertM. Juliana McElrathYunda HuangGeorgia D. TomarasNIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study TeamsNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kelly E. Seaton Aaron Deal Xue Han Shuying S. Li Ashley Clayton Jack Heptinstall Ann Duerr Mary A. Allen Xiaoying Shen Sheetal Sawant Nicole L. Yates Paul Spearman Gavin Churchyard Paul A. Goepfert Janine Maenza Glenda Gray Giuseppe Pantaleo Laura Polakowski Harriet L. Robinson Shannon Grant April K. Randhawa Ying Huang Cecilia Morgan Nicole Grunenberg Shelly Karuna Peter B. Gilbert M. Juliana McElrath Yunda Huang Georgia D. Tomaras NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
description	Abstract We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG.
format	article
author	Kelly E. Seaton Aaron Deal Xue Han Shuying S. Li Ashley Clayton Jack Heptinstall Ann Duerr Mary A. Allen Xiaoying Shen Sheetal Sawant Nicole L. Yates Paul Spearman Gavin Churchyard Paul A. Goepfert Janine Maenza Glenda Gray Giuseppe Pantaleo Laura Polakowski Harriet L. Robinson Shannon Grant April K. Randhawa Ying Huang Cecilia Morgan Nicole Grunenberg Shelly Karuna Peter B. Gilbert M. Juliana McElrath Yunda Huang Georgia D. Tomaras NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams
author_facet	Kelly E. Seaton Aaron Deal Xue Han Shuying S. Li Ashley Clayton Jack Heptinstall Ann Duerr Mary A. Allen Xiaoying Shen Sheetal Sawant Nicole L. Yates Paul Spearman Gavin Churchyard Paul A. Goepfert Janine Maenza Glenda Gray Giuseppe Pantaleo Laura Polakowski Harriet L. Robinson Shannon Grant April K. Randhawa Ying Huang Cecilia Morgan Nicole Grunenberg Shelly Karuna Peter B. Gilbert M. Juliana McElrath Yunda Huang Georgia D. Tomaras NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams
author_sort	Kelly E. Seaton
title	Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
title_short	Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
title_full	Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
title_fullStr	Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
title_full_unstemmed	Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
title_sort	meta-analysis of hiv-1 vaccine elicited mucosal antibodies in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f212191b8044471a09de9b169fd03d0
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Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

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