The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery

Research on the relationship between the geriatric nutritional risk index (GNRI) and postoperative complications/oncological outcomes in elderly colorectal cancer (CRC) patients is limited. This study investigated the prognostic value of the GNRI in aged CRC patients. We retrospectively analyzed 120...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chun-Kai Liao, Yih-Jong Chern, Yu-Jen Hsu, Yueh-Chen Lin, Yen-Lin Yu, Jy-Ming Chiang, Chien-Yuh Yeh, Jeng-Fu You
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	geriatric nutritional risk index (GNRI) colorectal cancer complication prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2f215c461a7044fc986deed52b59859d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f215c461a7044fc986deed52b59859d
record_format	dspace
spelling	oai:doaj.org-article:2f215c461a7044fc986deed52b59859d2021-11-25T17:04:44ZThe Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery10.3390/cancers132258522072-6694https://doaj.org/article/2f215c461a7044fc986deed52b59859d2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5852https://doaj.org/toc/2072-6694Research on the relationship between the geriatric nutritional risk index (GNRI) and postoperative complications/oncological outcomes in elderly colorectal cancer (CRC) patients is limited. This study investigated the prognostic value of the GNRI in aged CRC patients. We retrospectively analyzed 1206 consecutive CRC patients aged over 75 years who underwent curative-intent surgery from January 2008 to December 2015 and categorized them into high GNRI (≥98) and low GNRI (<98) groups according to a receiver operating characteristic (ROC) curve analysis. Uni- and multivariate logistic regression analysis were used to explore the association of the GNRI with postoperative complications. Kaplan–Meier survival analyses and the Cox proportional hazard model were used to explore the association between GNRI and survival. We discovered that GNRI is an independent risk factor for postoperative complications (HR: 1.774, <i>p</i> = 0.037). Surgical site infection, wound dehiscence and pneumonia were more common in patients with GNRI < 98. Survival analysis showed significantly worse overall survival and disease-free survival in the low GNRI group (both <i>p</i> < 0.001). In the multivariate analysis, GNRI < 98 was an independent risk factor for OS (HR: 1.329, <i>p</i> = 0.031) and DFS (HR: 1.312, <i>p</i> = 0.034). Thus, preoperative GNRI can be effectively used to predict postoperative complications and long-term survival in elderly CRC patients after curative surgery.Chun-Kai LiaoYih-Jong ChernYu-Jen HsuYueh-Chen LinYen-Lin YuJy-Ming ChiangChien-Yuh YehJeng-Fu YouMDPI AGarticlegeriatric nutritional risk index (GNRI)colorectal cancercomplicationprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5852, p 5852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	geriatric nutritional risk index (GNRI) colorectal cancer complication prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	geriatric nutritional risk index (GNRI) colorectal cancer complication prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chun-Kai Liao Yih-Jong Chern Yu-Jen Hsu Yueh-Chen Lin Yen-Lin Yu Jy-Ming Chiang Chien-Yuh Yeh Jeng-Fu You The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
description	Research on the relationship between the geriatric nutritional risk index (GNRI) and postoperative complications/oncological outcomes in elderly colorectal cancer (CRC) patients is limited. This study investigated the prognostic value of the GNRI in aged CRC patients. We retrospectively analyzed 1206 consecutive CRC patients aged over 75 years who underwent curative-intent surgery from January 2008 to December 2015 and categorized them into high GNRI (≥98) and low GNRI (<98) groups according to a receiver operating characteristic (ROC) curve analysis. Uni- and multivariate logistic regression analysis were used to explore the association of the GNRI with postoperative complications. Kaplan–Meier survival analyses and the Cox proportional hazard model were used to explore the association between GNRI and survival. We discovered that GNRI is an independent risk factor for postoperative complications (HR: 1.774, <i>p</i> = 0.037). Surgical site infection, wound dehiscence and pneumonia were more common in patients with GNRI < 98. Survival analysis showed significantly worse overall survival and disease-free survival in the low GNRI group (both <i>p</i> < 0.001). In the multivariate analysis, GNRI < 98 was an independent risk factor for OS (HR: 1.329, <i>p</i> = 0.031) and DFS (HR: 1.312, <i>p</i> = 0.034). Thus, preoperative GNRI can be effectively used to predict postoperative complications and long-term survival in elderly CRC patients after curative surgery.
format	article
author	Chun-Kai Liao Yih-Jong Chern Yu-Jen Hsu Yueh-Chen Lin Yen-Lin Yu Jy-Ming Chiang Chien-Yuh Yeh Jeng-Fu You
author_facet	Chun-Kai Liao Yih-Jong Chern Yu-Jen Hsu Yueh-Chen Lin Yen-Lin Yu Jy-Ming Chiang Chien-Yuh Yeh Jeng-Fu You
author_sort	Chun-Kai Liao
title	The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
title_short	The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
title_full	The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
title_fullStr	The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
title_full_unstemmed	The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery
title_sort	clinical utility of the geriatric nutritional risk index in predicting postoperative complications and long-term survival in elderly patients with colorectal cancer after curative surgery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2f215c461a7044fc986deed52b59859d
work_keys_str_mv	AT chunkailiao theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yihjongchern theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yujenhsu theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yuehchenlin theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yenlinyu theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT jymingchiang theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT chienyuhyeh theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT jengfuyou theclinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT chunkailiao clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yihjongchern clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yujenhsu clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yuehchenlin clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT yenlinyu clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT jymingchiang clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT chienyuhyeh clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery AT jengfuyou clinicalutilityofthegeriatricnutritionalriskindexinpredictingpostoperativecomplicationsandlongtermsurvivalinelderlypatientswithcolorectalcanceraftercurativesurgery
_version_	1718412704688898048

The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery

Ejemplares similares