An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid
This study displays the facile and fluent electrochemical determination of uric acid (UA) through exceptional copper oxide nanostructures (CuO), as an effective sensing probe. The copper oxide nanostructures were fabricated via an aqueous chemical growth method using sodium hydroxide as a reducing a...
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De Gruyter
2021
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oai:doaj.org-article:2f27817ba83a423d9edbf75a475521c32021-12-05T14:10:43ZAn improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid2391-542010.1515/chem-2021-0029https://doaj.org/article/2f27817ba83a423d9edbf75a475521c32021-04-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0029https://doaj.org/toc/2391-5420This study displays the facile and fluent electrochemical determination of uric acid (UA) through exceptional copper oxide nanostructures (CuO), as an effective sensing probe. The copper oxide nanostructures were fabricated via an aqueous chemical growth method using sodium hydroxide as a reducing agent, which massively hold hydroxide source. Copper oxide nanostructures showed astonishing electrocatalytic behavior in the detection of UA. Different characterization techniques such as XRD, FESEM, and EDS were exploited to determine crystalline nature, morphologies, and elemental composition of synthesized nanostructures. The cyclic voltammetry (CV) was subjected to investigate the electrochemical performance of UA using copper oxide nanostructures modified glassy carbon electrode CuO/GCE. The CV parameters were optimized at a scan rate of 50 mV/s with −0.7 to 0.9 potential range, and the UA response was investigated at 0.4 mV. PBS buffer of pH 7.4 was exploited as a supporting electrolyte. The linear dynamic range for UA was 0.001–351 mM with a very low limit of detection observed as 0.6 µM. The proposed sensor was successfully applied in urine samples for the detection of UA with improved sensitivity and selectivity.Buledi Jamil A.Ameen SidraMemon Saba A.Fatima AlmasSolangi Amber R.Mallah ArfanaKarimi FatemehMalakmohammadi SalimaAgarwal ShilpiGupta Vinod KumarDe Gruyterarticlecopper oxide nanostructureselectrochemical sensormodified sensoruric acid sensorChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 481-491 (2021) |
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copper oxide nanostructures electrochemical sensor modified sensor uric acid sensor Chemistry QD1-999 |
| spellingShingle |
copper oxide nanostructures electrochemical sensor modified sensor uric acid sensor Chemistry QD1-999 Buledi Jamil A. Ameen Sidra Memon Saba A. Fatima Almas Solangi Amber R. Mallah Arfana Karimi Fatemeh Malakmohammadi Salima Agarwal Shilpi Gupta Vinod Kumar An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| description |
This study displays the facile and fluent electrochemical determination of uric acid (UA) through exceptional copper oxide nanostructures (CuO), as an effective sensing probe. The copper oxide nanostructures were fabricated via an aqueous chemical growth method using sodium hydroxide as a reducing agent, which massively hold hydroxide source. Copper oxide nanostructures showed astonishing electrocatalytic behavior in the detection of UA. Different characterization techniques such as XRD, FESEM, and EDS were exploited to determine crystalline nature, morphologies, and elemental composition of synthesized nanostructures. The cyclic voltammetry (CV) was subjected to investigate the electrochemical performance of UA using copper oxide nanostructures modified glassy carbon electrode CuO/GCE. The CV parameters were optimized at a scan rate of 50 mV/s with −0.7 to 0.9 potential range, and the UA response was investigated at 0.4 mV. PBS buffer of pH 7.4 was exploited as a supporting electrolyte. The linear dynamic range for UA was 0.001–351 mM with a very low limit of detection observed as 0.6 µM. The proposed sensor was successfully applied in urine samples for the detection of UA with improved sensitivity and selectivity. |
| format |
article |
| author |
Buledi Jamil A. Ameen Sidra Memon Saba A. Fatima Almas Solangi Amber R. Mallah Arfana Karimi Fatemeh Malakmohammadi Salima Agarwal Shilpi Gupta Vinod Kumar |
| author_facet |
Buledi Jamil A. Ameen Sidra Memon Saba A. Fatima Almas Solangi Amber R. Mallah Arfana Karimi Fatemeh Malakmohammadi Salima Agarwal Shilpi Gupta Vinod Kumar |
| author_sort |
Buledi Jamil A. |
| title |
An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| title_short |
An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| title_full |
An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| title_fullStr |
An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| title_full_unstemmed |
An improved non-enzymatic electrochemical sensor amplified with CuO nanostructures for sensitive determination of uric acid |
| title_sort |
improved non-enzymatic electrochemical sensor amplified with cuo nanostructures for sensitive determination of uric acid |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/2f27817ba83a423d9edbf75a475521c3 |
| work_keys_str_mv |
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