VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS

A spectrophotometric method for determining cyanogenic glucosides (CGs) was validated in accordance with IUPAC and ICH requirements for new methods. The method demonstrates good linearity in the range of 0.1-0.88 μgg-1 hydrocyanic acid (HCN). The accuracy of the method ranges between 95.2% and 96.4%...

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Autores principales:	Darwin ORTIZ, Teresa SÁNCHEZ, Harold ACOSTA, Helena PACHÓN
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	Cyanogenic glucosides cassava hydrogen cyanide validation methods spectrophotometry. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/2f28a9c1a6ce4639a8d36421983c248a
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spelling	oai:doaj.org-article:2f28a9c1a6ce4639a8d36421983c248a2021-11-19T04:13:07ZVALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS0121-40042145-2660https://doaj.org/article/2f28a9c1a6ce4639a8d36421983c248a2011-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10681https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660A spectrophotometric method for determining cyanogenic glucosides (CGs) was validated in accordance with IUPAC and ICH requirements for new methods. The method demonstrates good linearity in the range of 0.1-0.88 μgg-1 hydrocyanic acid (HCN). The accuracy of the method ranges between 95.2% and 96.4%. The precision of the method, reflected as the relative standard deviation of the replicates, is lower than 12%. The method was compared with the most used method to detect CGs in cassava roots, the one established by Essers et al. Both methods were applied to quantify CGs in commercial cassava products. The new method is a useful and reliable tool for monitoring levels of CGs in cassava commercial products.Darwin ORTIZTeresa SÁNCHEZHarold ACOSTAHelena PACHÓNUniversidad de AntioquiaarticleCyanogenic glucosidescassavahydrogen cyanidevalidation methodsspectrophotometry.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 3 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cyanogenic glucosides cassava hydrogen cyanide validation methods spectrophotometry. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Cyanogenic glucosides cassava hydrogen cyanide validation methods spectrophotometry. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Darwin ORTIZ Teresa SÁNCHEZ Harold ACOSTA Helena PACHÓN VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
description	A spectrophotometric method for determining cyanogenic glucosides (CGs) was validated in accordance with IUPAC and ICH requirements for new methods. The method demonstrates good linearity in the range of 0.1-0.88 μgg-1 hydrocyanic acid (HCN). The accuracy of the method ranges between 95.2% and 96.4%. The precision of the method, reflected as the relative standard deviation of the replicates, is lower than 12%. The method was compared with the most used method to detect CGs in cassava roots, the one established by Essers et al. Both methods were applied to quantify CGs in commercial cassava products. The new method is a useful and reliable tool for monitoring levels of CGs in cassava commercial products.
format	article
author	Darwin ORTIZ Teresa SÁNCHEZ Harold ACOSTA Helena PACHÓN
author_facet	Darwin ORTIZ Teresa SÁNCHEZ Harold ACOSTA Helena PACHÓN
author_sort	Darwin ORTIZ
title	VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
title_short	VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
title_full	VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
title_fullStr	VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
title_full_unstemmed	VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS
title_sort	validation of an analytical methodology to quantify cyanogenic glucosides in commercial cassava products
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/2f28a9c1a6ce4639a8d36421983c248a
work_keys_str_mv	AT darwinortiz validationofananalyticalmethodologytoquantifycyanogenicglucosidesincommercialcassavaproducts AT teresasanchez validationofananalyticalmethodologytoquantifycyanogenicglucosidesincommercialcassavaproducts AT haroldacosta validationofananalyticalmethodologytoquantifycyanogenicglucosidesincommercialcassavaproducts AT helenapachon validationofananalyticalmethodologytoquantifycyanogenicglucosidesincommercialcassavaproducts
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VALIDATION OF AN ANALYTICAL METHODOLOGY TO QUANTIFY CYANOGENIC GLUCOSIDES IN COMMERCIAL CASSAVA PRODUCTS

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