Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature

Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of geneti...

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Autores principales:	Camille Invernizzi, Victor Gaultier, Philippe Guilbert, Christelle Jouannaud, Anne-Laure Labrousse, Charles Marchand Crety
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	pemphigus radiotherapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2f2be0a7a3c54b9f82e891b1cb9966e0
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spelling	oai:doaj.org-article:2f2be0a7a3c54b9f82e891b1cb9966e02021-12-02T12:40:23ZRecurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature1662-657510.1159/000520380https://doaj.org/article/2f2be0a7a3c54b9f82e891b1cb9966e02021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520380https://doaj.org/toc/1662-6575Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection, and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in the context of breast cancer treatment. We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple-negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. For more than three-quarters of the described cases in the literature, pemphigus occurs within 3 months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.Camille InvernizziVictor GaultierPhilippe GuilbertChristelle JouannaudAnne-Laure LabrousseCharles Marchand CretyKarger Publishersarticlepemphigusradiotherapybreast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1733-1740 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pemphigus radiotherapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pemphigus radiotherapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Camille Invernizzi Victor Gaultier Philippe Guilbert Christelle Jouannaud Anne-Laure Labrousse Charles Marchand Crety Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
description	Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection, and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in the context of breast cancer treatment. We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple-negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. For more than three-quarters of the described cases in the literature, pemphigus occurs within 3 months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.
format	article
author	Camille Invernizzi Victor Gaultier Philippe Guilbert Christelle Jouannaud Anne-Laure Labrousse Charles Marchand Crety
author_facet	Camille Invernizzi Victor Gaultier Philippe Guilbert Christelle Jouannaud Anne-Laure Labrousse Charles Marchand Crety
author_sort	Camille Invernizzi
title	Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
title_short	Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
title_full	Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
title_fullStr	Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
title_full_unstemmed	Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature
title_sort	recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/2f2be0a7a3c54b9f82e891b1cb9966e0
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Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature

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