Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease

Abstract Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatm...

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Autores principales:	R. Kobayashi, T. Kobayashi, F. Sakai, T. Hosoya, M. Yamamoto, T. Kurita-Ochiai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f2c9f85c5254cc2b91d419c8365e3e5
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spelling	oai:doaj.org-article:2f2c9f85c5254cc2b91d419c8365e3e52021-12-02T11:41:10ZOral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease10.1038/s41598-017-00623-92045-2322https://doaj.org/article/2f2c9f85c5254cc2b91d419c8365e3e52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00623-9https://doaj.org/toc/2045-2322Abstract Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection. Conversely, mouse β-defensin-14 (mBD-14) mRNA and its peptide products were significantly increased in distant mucosal components as well as the intestinal tract to which LG2055 was introduced. Moreover, IL-1β and TNF-α production from THP-1 monocytes stimulated with P. gingivalis antigen was significantly reduced by the addition of human β-defensin-3. These results suggest that gastrically administered LG2055 can enhance immunoregulation followed by periodontitis prevention in oral mucosa via the gut immune system; i.e., the possibility of homing in innate immunity.R. KobayashiT. KobayashiF. SakaiT. HosoyaM. YamamotoT. Kurita-OchiaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. Kobayashi T. Kobayashi F. Sakai T. Hosoya M. Yamamoto T. Kurita-Ochiai Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
description	Abstract Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection. Conversely, mouse β-defensin-14 (mBD-14) mRNA and its peptide products were significantly increased in distant mucosal components as well as the intestinal tract to which LG2055 was introduced. Moreover, IL-1β and TNF-α production from THP-1 monocytes stimulated with P. gingivalis antigen was significantly reduced by the addition of human β-defensin-3. These results suggest that gastrically administered LG2055 can enhance immunoregulation followed by periodontitis prevention in oral mucosa via the gut immune system; i.e., the possibility of homing in innate immunity.
format	article
author	R. Kobayashi T. Kobayashi F. Sakai T. Hosoya M. Yamamoto T. Kurita-Ochiai
author_facet	R. Kobayashi T. Kobayashi F. Sakai T. Hosoya M. Yamamoto T. Kurita-Ochiai
author_sort	R. Kobayashi
title	Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
title_short	Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
title_full	Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
title_fullStr	Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
title_full_unstemmed	Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease
title_sort	oral administration of lactobacillus gasseri sbt2055 is effective in preventing porphyromonas gingivalis-accelerated periodontal disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2f2c9f85c5254cc2b91d419c8365e3e5
work_keys_str_mv	AT rkobayashi oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease AT tkobayashi oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease AT fsakai oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease AT thosoya oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease AT myamamoto oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease AT tkuritaochiai oraladministrationoflactobacillusgasserisbt2055iseffectiveinpreventingporphyromonasgingivalisacceleratedperiodontaldisease
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Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease

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