Prospective study of efficacy and safety of insulin pump therapy in children and adolescents

Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the...

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Autores principales:	Andrey Olegovich Emel'yanov, Tamara Leonidovna Kuraeva, Dmitriy Nikitich Laptev, Valentina Alexandrovna Peterkova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	type 1 diabetes mellitus children and adolescents insulinotherapy insulin pump Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/2f2f8794898d4bb7ba8873b34f651cc6
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spelling	oai:doaj.org-article:2f2f8794898d4bb7ba8873b34f651cc62021-11-14T09:00:15ZProspective study of efficacy and safety of insulin pump therapy in children and adolescents2072-03512072-037810.14341/2072-0351-5503https://doaj.org/article/2f2f8794898d4bb7ba8873b34f651cc62010-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5503https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the most efficacious tool for the improvement of glycemic control.Aim. To estimate results of glycemic control in children and adolescents treated by insulin pump therapy. Materials and methods. The study included 173 patients aged 1.5-22 years having the disease for 0.5-20 years. MiniMed 508, MiniMed 712,MiniMed 722, Accu Check Spirit, Accu check D-Tron, Dana Care IIs pumps, ultrashort-acting insulins aspart and lispro were used. The patientsperformed self-control of glycemia 4-8 times during 24 hours. HbA1c was measured before and 12, 24, 36, 48 months after the onset of therapy. Thefrequency of DKA and severe hypoglycemia was recorded. Results. The HbA1c before the onset of therapy was 9.8 ?2.0% and dropped to 8.6; 8.7; 8.7; 8.9 and 9% 12, 24, 36, 48 months after it respectively.DKA was diagnosed in 20 (2.4%) and severe hypoglycemia in 5 patients. All patients in the CSII group were content with the use of the pumps, theabsence of injections and flexible day regimen. Conclusion. One year after the beginning of therapy the level of HbA1c significantly decreased. However, it increased again during a follow-up of5 years probably because of impaired compliance. This fact implies the necessity to regular repeat patient education for raising awareness of and motivationfor self-management.Andrey Olegovich Emel'yanovTamara Leonidovna KuraevaDmitriy Nikitich LaptevValentina Alexandrovna PeterkovaEndocrinology Research Centrearticletype 1 diabetes mellituschildren and adolescentsinsulinotherapyinsulin pumpNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 3, Pp 143-146 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus children and adolescents insulinotherapy insulin pump Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus children and adolescents insulinotherapy insulin pump Nutritional diseases. Deficiency diseases RC620-627 Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
description	Adequate glycemic control remains an unresolved problem for children and adolescents with type 1 diabetes mellitus. The use of new insulin analogsand intense insulinotherapy does not always permit to achieve the target levels of glycemia and HbA1c. To-day insulin pump therapy is considered tobe the most efficacious tool for the improvement of glycemic control.Aim. To estimate results of glycemic control in children and adolescents treated by insulin pump therapy. Materials and methods. The study included 173 patients aged 1.5-22 years having the disease for 0.5-20 years. MiniMed 508, MiniMed 712,MiniMed 722, Accu Check Spirit, Accu check D-Tron, Dana Care IIs pumps, ultrashort-acting insulins aspart and lispro were used. The patientsperformed self-control of glycemia 4-8 times during 24 hours. HbA1c was measured before and 12, 24, 36, 48 months after the onset of therapy. Thefrequency of DKA and severe hypoglycemia was recorded. Results. The HbA1c before the onset of therapy was 9.8 ?2.0% and dropped to 8.6; 8.7; 8.7; 8.9 and 9% 12, 24, 36, 48 months after it respectively.DKA was diagnosed in 20 (2.4%) and severe hypoglycemia in 5 patients. All patients in the CSII group were content with the use of the pumps, theabsence of injections and flexible day regimen. Conclusion. One year after the beginning of therapy the level of HbA1c significantly decreased. However, it increased again during a follow-up of5 years probably because of impaired compliance. This fact implies the necessity to regular repeat patient education for raising awareness of and motivationfor self-management.
format	article
author	Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova
author_facet	Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Dmitriy Nikitich Laptev Valentina Alexandrovna Peterkova
author_sort	Andrey Olegovich Emel'yanov
title	Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
title_short	Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
title_full	Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
title_fullStr	Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
title_full_unstemmed	Prospective study of efficacy and safety of insulin pump therapy in children and adolescents
title_sort	prospective study of efficacy and safety of insulin pump therapy in children and adolescents
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/2f2f8794898d4bb7ba8873b34f651cc6
work_keys_str_mv	AT andreyolegovichemelyanov prospectivestudyofefficacyandsafetyofinsulinpumptherapyinchildrenandadolescents AT tamaraleonidovnakuraeva prospectivestudyofefficacyandsafetyofinsulinpumptherapyinchildrenandadolescents AT dmitriynikitichlaptev prospectivestudyofefficacyandsafetyofinsulinpumptherapyinchildrenandadolescents AT valentinaalexandrovnapeterkova prospectivestudyofefficacyandsafetyofinsulinpumptherapyinchildrenandadolescents
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Prospective study of efficacy and safety of insulin pump therapy in children and adolescents

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