Micro RNAs: an arguable appraisal in medicine

Micro RNAs (miRNAs) represent a newly discovered class of regulatory molecules in the human body. miRNA is a short double stranded RNA sequence interfering with mRNA, causing in most cases, inhibition of translation. Synthesis of miRNAs shows an increasing developmental pattern and postnatally miRNA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Voglova K., Bezakova J., Herichova Iveta
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	biomarkers exosome therapeutics development cancer cardiovascular neural Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/2f3544580383410b90d7769f4f04a904
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f3544580383410b90d7769f4f04a904
record_format	dspace
spelling	oai:doaj.org-article:2f3544580383410b90d7769f4f04a9042021-12-02T16:33:00ZMicro RNAs: an arguable appraisal in medicine1336-032910.1515/enr-2016-0013https://doaj.org/article/2f3544580383410b90d7769f4f04a9042016-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0013https://doaj.org/toc/1336-0329Micro RNAs (miRNAs) represent a newly discovered class of regulatory molecules in the human body. miRNA is a short double stranded RNA sequence interfering with mRNA, causing in most cases, inhibition of translation. Synthesis of miRNAs shows an increasing developmental pattern and postnatally miRNAs are synthesized in all cells possessing transcriptional machinery. miRNAs usually target several mRNAs and therefore conclusive evidences proving their functions are not always ease to be acquired. In spite of this difficulty, functions of miRNAs were firmly established in the development, the cardiovascular and neural diseases, and cancer. Many miRNAs have been reported to be associated with physiological state of cells and/or tissues. This finding becomes fundamental, especially when consider that these miRNAs can be released from cell into intracellular space or circulation. Correlation between miRNA production in tissues and its contribution to multisource miRNA pool in the circulation is in a focus of biomarker-oriented researchers. Recently, circulating miRNAs have been suggested to be applicable as biomarkers in several types of cancer, cardiovascular injury, and diabetes. Role of miRNAs in the organism intercellular signaling is still under the broad investigation. Several miRNA mimics, intended for treatment of disease, are being currently tested in the clinical trials.Voglova K.Bezakova J.Herichova IvetaSciendoarticlebiomarkersexosometherapeuticsdevelopmentcancercardiovascularneuralDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 2, Pp 106-124 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarkers exosome therapeutics development cancer cardiovascular neural Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	biomarkers exosome therapeutics development cancer cardiovascular neural Diseases of the endocrine glands. Clinical endocrinology RC648-665 Voglova K. Bezakova J. Herichova Iveta Micro RNAs: an arguable appraisal in medicine
description	Micro RNAs (miRNAs) represent a newly discovered class of regulatory molecules in the human body. miRNA is a short double stranded RNA sequence interfering with mRNA, causing in most cases, inhibition of translation. Synthesis of miRNAs shows an increasing developmental pattern and postnatally miRNAs are synthesized in all cells possessing transcriptional machinery. miRNAs usually target several mRNAs and therefore conclusive evidences proving their functions are not always ease to be acquired. In spite of this difficulty, functions of miRNAs were firmly established in the development, the cardiovascular and neural diseases, and cancer. Many miRNAs have been reported to be associated with physiological state of cells and/or tissues. This finding becomes fundamental, especially when consider that these miRNAs can be released from cell into intracellular space or circulation. Correlation between miRNA production in tissues and its contribution to multisource miRNA pool in the circulation is in a focus of biomarker-oriented researchers. Recently, circulating miRNAs have been suggested to be applicable as biomarkers in several types of cancer, cardiovascular injury, and diabetes. Role of miRNAs in the organism intercellular signaling is still under the broad investigation. Several miRNA mimics, intended for treatment of disease, are being currently tested in the clinical trials.
format	article
author	Voglova K. Bezakova J. Herichova Iveta
author_facet	Voglova K. Bezakova J. Herichova Iveta
author_sort	Voglova K.
title	Micro RNAs: an arguable appraisal in medicine
title_short	Micro RNAs: an arguable appraisal in medicine
title_full	Micro RNAs: an arguable appraisal in medicine
title_fullStr	Micro RNAs: an arguable appraisal in medicine
title_full_unstemmed	Micro RNAs: an arguable appraisal in medicine
title_sort	micro rnas: an arguable appraisal in medicine
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/2f3544580383410b90d7769f4f04a904
work_keys_str_mv	AT voglovak micrornasanarguableappraisalinmedicine AT bezakovaj micrornasanarguableappraisalinmedicine AT herichovaiveta micrornasanarguableappraisalinmedicine
_version_	1718383800693555200

Micro RNAs: an arguable appraisal in medicine

Ejemplares similares