Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses
The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared t...
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Nature Portfolio
2019
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oai:doaj.org-article:2f369b436b384d20839dab99bd0c13c52021-12-02T15:35:39ZIron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses10.1038/s41467-019-11002-52041-1723https://doaj.org/article/2f369b436b384d20839dab99bd0c13c52019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11002-5https://doaj.org/toc/2041-1723The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls.Yuhang JiangCuifeng LiQian WuPeng AnLaiquan HuangJia WangChen ChenXi ChenFan ZhangLi MaSanhong LiuHanqing HeShuyun XieYangbai SunHanshao LiuYu ZhanYu TaoZhi LiuXiaohua SunYiming HuQi WangDeji YeJie ZhangShanhua ZouYing WangGang WeiYongzhong LiuYufang ShiY. Eugene ChinYongqiang HaoFudi WangXiaoren ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yuhang Jiang Cuifeng Li Qian Wu Peng An Laiquan Huang Jia Wang Chen Chen Xi Chen Fan Zhang Li Ma Sanhong Liu Hanqing He Shuyun Xie Yangbai Sun Hanshao Liu Yu Zhan Yu Tao Zhi Liu Xiaohua Sun Yiming Hu Qi Wang Deji Ye Jie Zhang Shanhua Zou Ying Wang Gang Wei Yongzhong Liu Yufang Shi Y. Eugene Chin Yongqiang Hao Fudi Wang Xiaoren Zhang Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| description |
The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls. |
| format |
article |
| author |
Yuhang Jiang Cuifeng Li Qian Wu Peng An Laiquan Huang Jia Wang Chen Chen Xi Chen Fan Zhang Li Ma Sanhong Liu Hanqing He Shuyun Xie Yangbai Sun Hanshao Liu Yu Zhan Yu Tao Zhi Liu Xiaohua Sun Yiming Hu Qi Wang Deji Ye Jie Zhang Shanhua Zou Ying Wang Gang Wei Yongzhong Liu Yufang Shi Y. Eugene Chin Yongqiang Hao Fudi Wang Xiaoren Zhang |
| author_facet |
Yuhang Jiang Cuifeng Li Qian Wu Peng An Laiquan Huang Jia Wang Chen Chen Xi Chen Fan Zhang Li Ma Sanhong Liu Hanqing He Shuyun Xie Yangbai Sun Hanshao Liu Yu Zhan Yu Tao Zhi Liu Xiaohua Sun Yiming Hu Qi Wang Deji Ye Jie Zhang Shanhua Zou Ying Wang Gang Wei Yongzhong Liu Yufang Shi Y. Eugene Chin Yongqiang Hao Fudi Wang Xiaoren Zhang |
| author_sort |
Yuhang Jiang |
| title |
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| title_short |
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| title_full |
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| title_fullStr |
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| title_full_unstemmed |
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses |
| title_sort |
iron-dependent histone 3 lysine 9 demethylation controls b cell proliferation and humoral immune responses |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2f369b436b384d20839dab99bd0c13c5 |
| work_keys_str_mv |
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