Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications

Min Gong, Song Wen, Thiquynhnga Nguyen, Chaoxun Wang, Jianlan Jin, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan Univers...

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Autores principales: Gong M, Wen S, Nguyen T, Wang C, Jin J, Zhou L
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:2f36ebe96bc34fe09e474144f4cde5972021-12-02T09:19:10ZConverging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications1178-7007https://doaj.org/article/2f36ebe96bc34fe09e474144f4cde5972020-03-01T00:00:00Zhttps://www.dovepress.com/converging-relationships-of-obesity-and-hyperuricemia-with-special-ref-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Min Gong, Song Wen, Thiquynhnga Nguyen, Chaoxun Wang, Jianlan Jin, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, ChinaTel +8613611927616Email zhouligang@yahoo.comBackground: Obesity and hyperuricemia mutually influence metabolic syndrome. This study discusses the metabolic relationships between obesity and hyperuricemia in terms of pathophysiology, complications, and treatments.Methods: We searched for preclinical or clinical studies on the pathophysiology, complications, and therapy of obesity and hyperuricemia on the PubMed database.Results: In this systemic review, we summarized our searching results on topics of pathophysiology, complications and therapeutic strategy. In pathophysiology, we firstly introduce genetic variations for obesity, hyperuricemia and their relationships by genetic studies. Secondly, we talk about the epigenetic influences on obesity and hyperuricemia. Thirdly, we describe the central metabolic regulation and the role of hyperuricemia. Then, we refer to the character of adipose tissue inflammation and oxidative stress in the obesity and hyperuricemia. In the last part of this topic, we reviewed the critical links of gut microbiota in the obesity and hyperuricemia. In the following part, we review the pathophysiology of major complications in obesity and hyperuricemia including insulin resistance and type 2 diabetes mellitus, chronic kidney disease, cardiovascular diseases, and cancers. Finally, we recapitulate the therapeutic strategies especially the novel pharmaceutic interventions for obesity and hyperuricemia, which concurrently show the mutual metabolic influences between two diseases.Conclusion: The data reviewed here delineate the metabolic relationships between obesity and hyperuricemia, and provide a comprehensive overview of the therapeutic targets for the management of metabolic syndromes.Keywords: obesity, hyperuricemia, pathophysiology, complication, pharmacotherapyGong MWen SNguyen TWang CJin JZhou LDove Medical PressarticleobesityhyperuricemiapathophysiologycomplicationpharmacotherapySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 943-962 (2020)
institution DOAJ
collection DOAJ
language EN
topic obesity
hyperuricemia
pathophysiology
complication
pharmacotherapy
Specialties of internal medicine
RC581-951
spellingShingle obesity
hyperuricemia
pathophysiology
complication
pharmacotherapy
Specialties of internal medicine
RC581-951
Gong M
Wen S
Nguyen T
Wang C
Jin J
Zhou L
Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
description Min Gong, Song Wen, Thiquynhnga Nguyen, Chaoxun Wang, Jianlan Jin, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, ChinaTel +8613611927616Email zhouligang@yahoo.comBackground: Obesity and hyperuricemia mutually influence metabolic syndrome. This study discusses the metabolic relationships between obesity and hyperuricemia in terms of pathophysiology, complications, and treatments.Methods: We searched for preclinical or clinical studies on the pathophysiology, complications, and therapy of obesity and hyperuricemia on the PubMed database.Results: In this systemic review, we summarized our searching results on topics of pathophysiology, complications and therapeutic strategy. In pathophysiology, we firstly introduce genetic variations for obesity, hyperuricemia and their relationships by genetic studies. Secondly, we talk about the epigenetic influences on obesity and hyperuricemia. Thirdly, we describe the central metabolic regulation and the role of hyperuricemia. Then, we refer to the character of adipose tissue inflammation and oxidative stress in the obesity and hyperuricemia. In the last part of this topic, we reviewed the critical links of gut microbiota in the obesity and hyperuricemia. In the following part, we review the pathophysiology of major complications in obesity and hyperuricemia including insulin resistance and type 2 diabetes mellitus, chronic kidney disease, cardiovascular diseases, and cancers. Finally, we recapitulate the therapeutic strategies especially the novel pharmaceutic interventions for obesity and hyperuricemia, which concurrently show the mutual metabolic influences between two diseases.Conclusion: The data reviewed here delineate the metabolic relationships between obesity and hyperuricemia, and provide a comprehensive overview of the therapeutic targets for the management of metabolic syndromes.Keywords: obesity, hyperuricemia, pathophysiology, complication, pharmacotherapy
format article
author Gong M
Wen S
Nguyen T
Wang C
Jin J
Zhou L
author_facet Gong M
Wen S
Nguyen T
Wang C
Jin J
Zhou L
author_sort Gong M
title Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
title_short Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
title_full Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
title_fullStr Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
title_full_unstemmed Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
title_sort converging relationships of obesity and hyperuricemia with special reference to metabolic disorders and plausible therapeutic implications
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/2f36ebe96bc34fe09e474144f4cde597
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AT nguyent convergingrelationshipsofobesityandhyperuricemiawithspecialreferencetometabolicdisordersandplausibletherapeuticimplications
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AT jinj convergingrelationshipsofobesityandhyperuricemiawithspecialreferencetometabolicdisordersandplausibletherapeuticimplications
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