Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease
Yang Hu,1 Peng Guo,1 Teng-Hong Lian,1 Li-Jun Zuo,1 Shu-Yang Yu,1 Li Liu,2 Zhao Jin,1 Qiu-Jin Yu,1 Rui-Dan Wang,1 Li-Xia Li,2 Ying-Shan Piao,3 Wei Zhang3– 7 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China;...
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Dove Medical Press
2021
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oai:doaj.org-article:2f3bebe2720d4e469303c4758d8ba1d02021-12-02T18:01:33ZClinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease1178-2021https://doaj.org/article/2f3bebe2720d4e469303c4758d8ba1d02021-06-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-iron-metabolism-and-neuroinflammation-new-ins-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Yang Hu,1 Peng Guo,1 Teng-Hong Lian,1 Li-Jun Zuo,1 Shu-Yang Yu,1 Li Liu,2 Zhao Jin,1 Qiu-Jin Yu,1 Rui-Dan Wang,1 Li-Xia Li,2 Ying-Shan Piao,3 Wei Zhang3– 7 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 3Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 4China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of China; 5Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, People’s Republic of China; 6Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, People’s Republic of China; 7Beijing Key Laboratory on Parkinson’s Disease, Beijing, 100053, People’s Republic of ChinaCorrespondence: Wei ZhangCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of ChinaTel +8613911996107Fax +86-10-59978429Email ttyyzw@163.comBackground: To investigate the clinical characteristics, iron metabolism and neuroinflammation in Parkinson’s disease (PD) patients with excessive daytime sleepiness (EDS).Methods: We studied 379 patients with PD and 30 age-matched controls. All subjects were evaluated by Epworth sleepiness scale (ESS) and a series of rating scales and were divided into PD-EDS and PD-NEDS groups according to ESS score. The concentrations of iron and iron-related proteins and inflammatory cytokines in both cerebrospinal fluid (CSF) and serum were examined.Results: 1. The occurrence rate of EDS in total PD patients was 16.09%. 2. PD-EDS group had significantly severer disease stages, more severe motor and non-motor features of the disease. 3. In CSF, the concentrations of iron and IL-1β in the PD-EDS group were significantly higher and ferritin concentration was prominently lower when compared with the PD-NEDS group and the control group; ESS score was significantly associated with high concentrations of iron and IL-1β and low concentration of ferritin in the PD group. Iron concentration was positively correlated with IL-1β concentration in the PD-EDS group. 4. In serum, no changes were observed in iron and iron-related proteins and inflammatory cytokines among the three groups.Conclusion: EDS was a common symptom in PD patients. PD patients with EDS had more severe motor and some non-motor symptoms. Overloaded iron-relevant inflammation in the brain might be an underlying mechanism of PD-EDS.Keywords: Parkinson disease, excessive daytime sleepiness, clinical features, iron metabolism, inflammationHu YGuo PLian THZuo LJYu SYLiu LJin ZYu QJWang RDLi LXPiao YSZhang WDove Medical Pressarticleparkinson diseaseexcessive daytime sleepinessclinical featuresiron metabolisminflammationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2041-2051 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
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parkinson disease excessive daytime sleepiness clinical features iron metabolism inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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parkinson disease excessive daytime sleepiness clinical features iron metabolism inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hu Y Guo P Lian TH Zuo LJ Yu SY Liu L Jin Z Yu QJ Wang RD Li LX Piao YS Zhang W Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| description |
Yang Hu,1 Peng Guo,1 Teng-Hong Lian,1 Li-Jun Zuo,1 Shu-Yang Yu,1 Li Liu,2 Zhao Jin,1 Qiu-Jin Yu,1 Rui-Dan Wang,1 Li-Xia Li,2 Ying-Shan Piao,3 Wei Zhang3– 7 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 3Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 4China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of China; 5Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, People’s Republic of China; 6Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, People’s Republic of China; 7Beijing Key Laboratory on Parkinson’s Disease, Beijing, 100053, People’s Republic of ChinaCorrespondence: Wei ZhangCenter for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of ChinaTel +8613911996107Fax +86-10-59978429Email ttyyzw@163.comBackground: To investigate the clinical characteristics, iron metabolism and neuroinflammation in Parkinson’s disease (PD) patients with excessive daytime sleepiness (EDS).Methods: We studied 379 patients with PD and 30 age-matched controls. All subjects were evaluated by Epworth sleepiness scale (ESS) and a series of rating scales and were divided into PD-EDS and PD-NEDS groups according to ESS score. The concentrations of iron and iron-related proteins and inflammatory cytokines in both cerebrospinal fluid (CSF) and serum were examined.Results: 1. The occurrence rate of EDS in total PD patients was 16.09%. 2. PD-EDS group had significantly severer disease stages, more severe motor and non-motor features of the disease. 3. In CSF, the concentrations of iron and IL-1β in the PD-EDS group were significantly higher and ferritin concentration was prominently lower when compared with the PD-NEDS group and the control group; ESS score was significantly associated with high concentrations of iron and IL-1β and low concentration of ferritin in the PD group. Iron concentration was positively correlated with IL-1β concentration in the PD-EDS group. 4. In serum, no changes were observed in iron and iron-related proteins and inflammatory cytokines among the three groups.Conclusion: EDS was a common symptom in PD patients. PD patients with EDS had more severe motor and some non-motor symptoms. Overloaded iron-relevant inflammation in the brain might be an underlying mechanism of PD-EDS.Keywords: Parkinson disease, excessive daytime sleepiness, clinical features, iron metabolism, inflammation |
| format |
article |
| author |
Hu Y Guo P Lian TH Zuo LJ Yu SY Liu L Jin Z Yu QJ Wang RD Li LX Piao YS Zhang W |
| author_facet |
Hu Y Guo P Lian TH Zuo LJ Yu SY Liu L Jin Z Yu QJ Wang RD Li LX Piao YS Zhang W |
| author_sort |
Hu Y |
| title |
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| title_short |
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| title_full |
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| title_fullStr |
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| title_full_unstemmed |
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease |
| title_sort |
clinical characteristics, iron metabolism and neuroinflammation: new insight into excessive daytime sleepiness in parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/2f3bebe2720d4e469303c4758d8ba1d0 |
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