The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.

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Autores principales:	Anne Wolf, Marc Herb, Michael Schramm, Thomas Langmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f3c188a202d4b068ecd2781ac80e7eb
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spelling	oai:doaj.org-article:2f3c188a202d4b068ecd2781ac80e7eb2021-12-02T17:50:39ZThe TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye10.1038/s41467-020-16400-82041-1723https://doaj.org/article/2f3c188a202d4b068ecd2781ac80e7eb2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16400-8https://doaj.org/toc/2041-1723Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.Anne WolfMarc HerbMichael SchrammThomas LangmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Wolf Marc Herb Michael Schramm Thomas Langmann The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
description	Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.
format	article
author	Anne Wolf Marc Herb Michael Schramm Thomas Langmann
author_facet	Anne Wolf Marc Herb Michael Schramm Thomas Langmann
author_sort	Anne Wolf
title	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
title_short	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
title_full	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
title_fullStr	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
title_full_unstemmed	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye
title_sort	tspo-nox1 axis controls phagocyte-triggered pathological angiogenesis in the eye
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2f3c188a202d4b068ecd2781ac80e7eb
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The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

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