Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs i...

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Autores principales:	Julia Vaynberg, Koichi Fukuda, Fan Lu, Katarzyna Bialkowska, Yinghua Chen, Edward F. Plow, Jun Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f3ee0e1efef44c1a464d2f52bd1fe13
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spelling	oai:doaj.org-article:2f3ee0e1efef44c1a464d2f52bd1fe132021-12-02T14:41:06ZNon-catalytic signaling by pseudokinase ILK for regulating cell adhesion10.1038/s41467-018-06906-72041-1723https://doaj.org/article/2f3ee0e1efef44c1a464d2f52bd1fe132018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06906-7https://doaj.org/toc/2041-1723Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs in PINCH and ParvinJulia VaynbergKoichi FukudaFan LuKatarzyna BialkowskaYinghua ChenEdward F. PlowJun QinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Vaynberg Koichi Fukuda Fan Lu Katarzyna Bialkowska Yinghua Chen Edward F. Plow Jun Qin Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
description	Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs in PINCH and Parvin
format	article
author	Julia Vaynberg Koichi Fukuda Fan Lu Katarzyna Bialkowska Yinghua Chen Edward F. Plow Jun Qin
author_facet	Julia Vaynberg Koichi Fukuda Fan Lu Katarzyna Bialkowska Yinghua Chen Edward F. Plow Jun Qin
author_sort	Julia Vaynberg
title	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
title_short	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
title_full	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
title_fullStr	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
title_full_unstemmed	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion
title_sort	non-catalytic signaling by pseudokinase ilk for regulating cell adhesion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2f3ee0e1efef44c1a464d2f52bd1fe13
work_keys_str_mv	AT juliavaynberg noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT koichifukuda noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT fanlu noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT katarzynabialkowska noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT yinghuachen noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT edwardfplow noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion AT junqin noncatalyticsignalingbypseudokinaseilkforregulatingcelladhesion
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Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

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