Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs i...

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Autores principales: Julia Vaynberg, Koichi Fukuda, Fan Lu, Katarzyna Bialkowska, Yinghua Chen, Edward F. Plow, Jun Qin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2f3ee0e1efef44c1a464d2f52bd1fe13
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