The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment

Invasion and metastasis are the main reasons for the high mortality of liver cancer, which involve the interaction of tumor stromal cells and malignant cells. Cancer-associated fibroblasts (CAFs) are one of the major constituents of tumor stromal cells affecting tumor growth, invasion, and metastasi...

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Autores principales:	Wentao Jia, Shufang Liang, Binbin Cheng, Changquan Ling
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cancer-associated fibroblasts (CAFs) traditional Chinese medicine hepatocellular carcinoma (HCC) stromal cell tumor recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2f427694a15941078c50bed476b3d803
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spelling	oai:doaj.org-article:2f427694a15941078c50bed476b3d8032021-11-18T04:50:24ZThe Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment2234-943X10.3389/fonc.2021.763519https://doaj.org/article/2f427694a15941078c50bed476b3d8032021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.763519/fullhttps://doaj.org/toc/2234-943XInvasion and metastasis are the main reasons for the high mortality of liver cancer, which involve the interaction of tumor stromal cells and malignant cells. Cancer-associated fibroblasts (CAFs) are one of the major constituents of tumor stromal cells affecting tumor growth, invasion, and metastasis. The heterogeneous properties and sources of CAFs make both tumor-supporting and tumor-suppression effects possible. The mechanisms for CAFs in supporting hepatocellular carcinoma (HCC) progression can be categorized into upregulated aggressiveness and stemness, transformed metabolism toward glycolysis and glutamine reductive carboxylation, polarized tumor immunity toward immune escape of HCC cells, and increased angiogenesis. The tumor-suppressive effect of fibroblasts highlights the functional heterogenicity of CAF populations and provides new insights into tumor–stromal interplay mechanisms. In this review, we introduced several key inflammatory signaling pathways in the transformation of CAFs from normal stromal cells and the heterogeneous biofunctions of activated CAFs. In view of the pleiotropic regulation properties of traditional Chinese medicine (TCM) and heterogeneous effects of CAFs, we also introduced the application and values of TCM in the treatment of HCC through targeting CAFs.Wentao JiaShufang LiangBinbin ChengChangquan LingFrontiers Media S.A.articlecancer-associated fibroblasts (CAFs)traditional Chinese medicinehepatocellular carcinoma (HCC)stromal celltumor recurrenceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer-associated fibroblasts (CAFs) traditional Chinese medicine hepatocellular carcinoma (HCC) stromal cell tumor recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer-associated fibroblasts (CAFs) traditional Chinese medicine hepatocellular carcinoma (HCC) stromal cell tumor recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wentao Jia Shufang Liang Binbin Cheng Changquan Ling The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
description	Invasion and metastasis are the main reasons for the high mortality of liver cancer, which involve the interaction of tumor stromal cells and malignant cells. Cancer-associated fibroblasts (CAFs) are one of the major constituents of tumor stromal cells affecting tumor growth, invasion, and metastasis. The heterogeneous properties and sources of CAFs make both tumor-supporting and tumor-suppression effects possible. The mechanisms for CAFs in supporting hepatocellular carcinoma (HCC) progression can be categorized into upregulated aggressiveness and stemness, transformed metabolism toward glycolysis and glutamine reductive carboxylation, polarized tumor immunity toward immune escape of HCC cells, and increased angiogenesis. The tumor-suppressive effect of fibroblasts highlights the functional heterogenicity of CAF populations and provides new insights into tumor–stromal interplay mechanisms. In this review, we introduced several key inflammatory signaling pathways in the transformation of CAFs from normal stromal cells and the heterogeneous biofunctions of activated CAFs. In view of the pleiotropic regulation properties of traditional Chinese medicine (TCM) and heterogeneous effects of CAFs, we also introduced the application and values of TCM in the treatment of HCC through targeting CAFs.
format	article
author	Wentao Jia Shufang Liang Binbin Cheng Changquan Ling
author_facet	Wentao Jia Shufang Liang Binbin Cheng Changquan Ling
author_sort	Wentao Jia
title	The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
title_short	The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
title_full	The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
title_fullStr	The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
title_full_unstemmed	The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment
title_sort	role of cancer-associated fibroblasts in hepatocellular carcinoma and the value of traditional chinese medicine treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2f427694a15941078c50bed476b3d803
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The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment

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