Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.

<h4>Background</h4>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the p...

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Autores principales:	Michael T Treadway, Merida M Grant, Zhaohua Ding, Steven D Hollon, John C Gore, Richard C Shelton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f446062d0c5411aa53d377e410e71b2
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id	oai:doaj.org-article:2f446062d0c5411aa53d377e410e71b2
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spelling	oai:doaj.org-article:2f446062d0c5411aa53d377e410e71b22021-11-25T06:16:29ZEarly adverse events, HPA activity and rostral anterior cingulate volume in MDD.1932-620310.1371/journal.pone.0004887https://doaj.org/article/2f446062d0c5411aa53d377e410e71b22009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19325704/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.<h4>Methods/results</h4>Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.<h4>Conclusions</h4>These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD.Michael T TreadwayMerida M GrantZhaohua DingSteven D HollonJohn C GoreRichard C SheltonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 3, p e4887 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael T Treadway Merida M Grant Zhaohua Ding Steven D Hollon John C Gore Richard C Shelton Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
description	<h4>Background</h4>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.<h4>Methods/results</h4>Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.<h4>Conclusions</h4>These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD.
format	article
author	Michael T Treadway Merida M Grant Zhaohua Ding Steven D Hollon John C Gore Richard C Shelton
author_facet	Michael T Treadway Merida M Grant Zhaohua Ding Steven D Hollon John C Gore Richard C Shelton
author_sort	Michael T Treadway
title	Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
title_short	Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
title_full	Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
title_fullStr	Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
title_full_unstemmed	Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.
title_sort	early adverse events, hpa activity and rostral anterior cingulate volume in mdd.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/2f446062d0c5411aa53d377e410e71b2
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Early adverse events, HPA activity and rostral anterior cingulate volume in MDD.

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