Lipid-protein interactions modulate the conformational equilibrium of a potassium channel

Potassium (K+) channels, such as MthK, are essentional for many biological processes, but how lipid-protein interactions regulate ion permeation of K+ channels remained unclear. Here authors conducted molecular dynamics simulations of MthK and observed different ion permeation rates of MthK in membr...

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Autores principales:	Ruo-Xu Gu, Bert L. de Groot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f45c0ab4da146a5bacd4019c7fbca93
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spelling	oai:doaj.org-article:2f45c0ab4da146a5bacd4019c7fbca932021-12-02T14:42:56ZLipid-protein interactions modulate the conformational equilibrium of a potassium channel10.1038/s41467-020-15741-82041-1723https://doaj.org/article/2f45c0ab4da146a5bacd4019c7fbca932020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15741-8https://doaj.org/toc/2041-1723Potassium (K+) channels, such as MthK, are essentional for many biological processes, but how lipid-protein interactions regulate ion permeation of K+ channels remained unclear. Here authors conducted molecular dynamics simulations of MthK and observed different ion permeation rates of MthK in membranes with different properties.Ruo-Xu GuBert L. de GrootNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruo-Xu Gu Bert L. de Groot Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
description	Potassium (K+) channels, such as MthK, are essentional for many biological processes, but how lipid-protein interactions regulate ion permeation of K+ channels remained unclear. Here authors conducted molecular dynamics simulations of MthK and observed different ion permeation rates of MthK in membranes with different properties.
format	article
author	Ruo-Xu Gu Bert L. de Groot
author_facet	Ruo-Xu Gu Bert L. de Groot
author_sort	Ruo-Xu Gu
title	Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
title_short	Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
title_full	Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
title_fullStr	Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
title_full_unstemmed	Lipid-protein interactions modulate the conformational equilibrium of a potassium channel
title_sort	lipid-protein interactions modulate the conformational equilibrium of a potassium channel
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2f45c0ab4da146a5bacd4019c7fbca93
work_keys_str_mv	AT ruoxugu lipidproteininteractionsmodulatetheconformationalequilibriumofapotassiumchannel AT bertldegroot lipidproteininteractionsmodulatetheconformationalequilibriumofapotassiumchannel
_version_	1718389558305882112

Lipid-protein interactions modulate the conformational equilibrium of a potassium channel

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