Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up

Abstract The burden of type 2 diabetes is growing, not only through increased incidence, but also through its comorbidities. Concordant comorbidities for type 2 diabetes, such as cardiovascular diseases, are considered expected outcomes of the disease or disease complications, while discordant comor...

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Autores principales:	Sophia Eilat-Tsanani, Avital Margalit, Liran Nevet Golan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f47ec89e0e9477bb2bc99b54413192f
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spelling	oai:doaj.org-article:2f47ec89e0e9477bb2bc99b54413192f2021-12-02T14:47:38ZOccurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up10.1038/s41598-021-90379-02045-2322https://doaj.org/article/2f47ec89e0e9477bb2bc99b54413192f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90379-0https://doaj.org/toc/2045-2322Abstract The burden of type 2 diabetes is growing, not only through increased incidence, but also through its comorbidities. Concordant comorbidities for type 2 diabetes, such as cardiovascular diseases, are considered expected outcomes of the disease or disease complications, while discordant comorbidities are not considered to be directly related to type 2 diabetes and are less extensively addressed under diabetes management. Here we show that the combination of concordant and discordant comorbidities appears frequently in persons with diabetes (75%). Persons with combined comorbidities visited family physicians more than persons with discordant, concordant or no comorbidity (17.3 ± 10.2, 11.6 ± 6.5, 8.7 ± 6.8, 6.3 ± 6.6 visits/person/year respectively, p < 0.0001). The risk of death during the study period was highest in persons with combined comorbidities and discordant only comorbidities (HR = 33.4; 95% CI 12.5–89.2 and HR = 33.5; 95% CI 11.7–95.8), emphasizing the contribution of discordant comorbidities to the outcome. Our study is unique as a long-term follow-up of an 11-year cohort of 9725 persons with new-onset type 2 diabetes. The findings highlight the contribution of discordant comorbidity to the burden of the disease. The high prevalence of the combination of both concordant and discordant comorbidities, and their appearance before the onset of type 2 diabetes, indicates a continuum of morbidity.Sophia Eilat-TsananiAvital MargalitLiran Nevet GolanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sophia Eilat-Tsanani Avital Margalit Liran Nevet Golan Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
description	Abstract The burden of type 2 diabetes is growing, not only through increased incidence, but also through its comorbidities. Concordant comorbidities for type 2 diabetes, such as cardiovascular diseases, are considered expected outcomes of the disease or disease complications, while discordant comorbidities are not considered to be directly related to type 2 diabetes and are less extensively addressed under diabetes management. Here we show that the combination of concordant and discordant comorbidities appears frequently in persons with diabetes (75%). Persons with combined comorbidities visited family physicians more than persons with discordant, concordant or no comorbidity (17.3 ± 10.2, 11.6 ± 6.5, 8.7 ± 6.8, 6.3 ± 6.6 visits/person/year respectively, p < 0.0001). The risk of death during the study period was highest in persons with combined comorbidities and discordant only comorbidities (HR = 33.4; 95% CI 12.5–89.2 and HR = 33.5; 95% CI 11.7–95.8), emphasizing the contribution of discordant comorbidities to the outcome. Our study is unique as a long-term follow-up of an 11-year cohort of 9725 persons with new-onset type 2 diabetes. The findings highlight the contribution of discordant comorbidity to the burden of the disease. The high prevalence of the combination of both concordant and discordant comorbidities, and their appearance before the onset of type 2 diabetes, indicates a continuum of morbidity.
format	article
author	Sophia Eilat-Tsanani Avital Margalit Liran Nevet Golan
author_facet	Sophia Eilat-Tsanani Avital Margalit Liran Nevet Golan
author_sort	Sophia Eilat-Tsanani
title	Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
title_short	Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
title_full	Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
title_fullStr	Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
title_full_unstemmed	Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
title_sort	occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f47ec89e0e9477bb2bc99b54413192f
work_keys_str_mv	AT sophiaeilattsanani occurrenceofcomorbiditiesinnewlydiagnosedtype2diabetespatientsandtheirimpactafter11yearsfollowup AT avitalmargalit occurrenceofcomorbiditiesinnewlydiagnosedtype2diabetespatientsandtheirimpactafter11yearsfollowup AT lirannevetgolan occurrenceofcomorbiditiesinnewlydiagnosedtype2diabetespatientsandtheirimpactafter11yearsfollowup
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Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years’ follow-up

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