MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.

Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized cutaneous (CL), and metastatic leishmaniasis. Metastasizing disease forms including disseminated (DCL) and mutocutaneous (MCL) leishmaniasis result from parasitic dissemination and lesion formation at...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Annette Ives, Slavica Masina, Patrik Castiglioni, Florence Prével, Mélanie Revaz-Breton, Mary-Anne Hartley, Pascal Launois, Nicolas Fasel, Catherine Ronet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f498dd9a460432bba9deb143fe9d8f4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f498dd9a460432bba9deb143fe9d8f4
record_format	dspace
spelling	oai:doaj.org-article:2f498dd9a460432bba9deb143fe9d8f42021-11-18T08:20:35ZMyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.1932-620310.1371/journal.pone.0096766https://doaj.org/article/2f498dd9a460432bba9deb143fe9d8f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24801628/?tool=EBIhttps://doaj.org/toc/1932-6203Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized cutaneous (CL), and metastatic leishmaniasis. Metastasizing disease forms including disseminated (DCL) and mutocutaneous (MCL) leishmaniasis result from parasitic dissemination and lesion formation at sites distal to infection and have increased inflammatory responses. The presence of Leishmania RNA virus (LRV) in L. guyanensis parasites contributes to the exacerbation of disease and impacts inflammatory responses via activation of TLR3 by the viral dsRNA. In this study we investigated other innate immune response adaptor protein modulators and demonstrated that both MyD88 and TLR9 played a crucial role in the development of Th1-dependent healing responses against L. guyanensis parasites regardless of their LRV status. The absence of MyD88- or TLR9-dependent signaling pathways resulted in increased Th2 associated cytokines (IL-4 and IL-13), which was correlated with low transcript levels of IL-12p40. The reliance of IL-12 was further confirmed in IL12AB-/- mice, which were completely susceptible to infection. Protection to L. guyanensis infection driven by MyD88- and TLR9-dependent immune responses arises independently to those induced due to high LRV burden within the parasites.Annette IvesSlavica MasinaPatrik CastiglioniFlorence PrévelMélanie Revaz-BretonMary-Anne HartleyPascal LaunoisNicolas FaselCatherine RonetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96766 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annette Ives Slavica Masina Patrik Castiglioni Florence Prével Mélanie Revaz-Breton Mary-Anne Hartley Pascal Launois Nicolas Fasel Catherine Ronet MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
description	Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized cutaneous (CL), and metastatic leishmaniasis. Metastasizing disease forms including disseminated (DCL) and mutocutaneous (MCL) leishmaniasis result from parasitic dissemination and lesion formation at sites distal to infection and have increased inflammatory responses. The presence of Leishmania RNA virus (LRV) in L. guyanensis parasites contributes to the exacerbation of disease and impacts inflammatory responses via activation of TLR3 by the viral dsRNA. In this study we investigated other innate immune response adaptor protein modulators and demonstrated that both MyD88 and TLR9 played a crucial role in the development of Th1-dependent healing responses against L. guyanensis parasites regardless of their LRV status. The absence of MyD88- or TLR9-dependent signaling pathways resulted in increased Th2 associated cytokines (IL-4 and IL-13), which was correlated with low transcript levels of IL-12p40. The reliance of IL-12 was further confirmed in IL12AB-/- mice, which were completely susceptible to infection. Protection to L. guyanensis infection driven by MyD88- and TLR9-dependent immune responses arises independently to those induced due to high LRV burden within the parasites.
format	article
author	Annette Ives Slavica Masina Patrik Castiglioni Florence Prével Mélanie Revaz-Breton Mary-Anne Hartley Pascal Launois Nicolas Fasel Catherine Ronet
author_facet	Annette Ives Slavica Masina Patrik Castiglioni Florence Prével Mélanie Revaz-Breton Mary-Anne Hartley Pascal Launois Nicolas Fasel Catherine Ronet
author_sort	Annette Ives
title	MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
title_short	MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
title_full	MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
title_fullStr	MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
title_full_unstemmed	MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.
title_sort	myd88 and tlr9 dependent immune responses mediate resistance to leishmania guyanensis infections, irrespective of leishmania rna virus burden.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2f498dd9a460432bba9deb143fe9d8f4
work_keys_str_mv	AT annetteives myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT slavicamasina myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT patrikcastiglioni myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT florenceprevel myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT melanierevazbreton myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT maryannehartley myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT pascallaunois myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT nicolasfasel myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden AT catherineronet myd88andtlr9dependentimmuneresponsesmediateresistancetoleishmaniaguyanensisinfectionsirrespectiveofleishmaniarnavirusburden
_version_	1718421851554709504

MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden.

Ejemplares similares