Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria

Abstract The population of bumble bees and other pollinators has considerably declined worldwide, probably, due to the toxic effect of pesticides used in agriculture. Inexpensive and available antidotes can be one of the solutions for the problem of pesticide toxicity for pollinators. We studied the...

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Autores principales:	Mikhail Syromyatnikov, Ekaterina Nesterova, Tatiana Smirnova, Vasily Popov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f4b3579ce124b37a527810979339946
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spelling	oai:doaj.org-article:2f4b3579ce124b37a5278109793399462021-12-02T16:50:24ZMethylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria10.1038/s41598-021-94231-32045-2322https://doaj.org/article/2f4b3579ce124b37a5278109793399462021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94231-3https://doaj.org/toc/2045-2322Abstract The population of bumble bees and other pollinators has considerably declined worldwide, probably, due to the toxic effect of pesticides used in agriculture. Inexpensive and available antidotes can be one of the solutions for the problem of pesticide toxicity for pollinators. We studied the properties of the thiazine dye Methylene blue (MB) as an antidote against the toxic action of pesticides in the bumble bee mitochondria and found that MB stimulated mitochondrial respiration mediated by Complex I of the electron transport chain (ETC) and increased respiration of the mitochondria treated with mitochondria-targeted (chlorfenapyr, hydramethylnon, pyridaben, tolfenpyrad, and fenazaquin) and non-mitochondrial (deltamethrin, metribuzin, and penconazole) pesticides. MB also restored the mitochondrial membrane potential dissipated by the pesticides affecting the ETC. The mechanism of MB action is most probably related to its ability to shunt electron flow in the mitochondrial ETC.Mikhail SyromyatnikovEkaterina NesterovaTatiana SmirnovaVasily PopovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikhail Syromyatnikov Ekaterina Nesterova Tatiana Smirnova Vasily Popov Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
description	Abstract The population of bumble bees and other pollinators has considerably declined worldwide, probably, due to the toxic effect of pesticides used in agriculture. Inexpensive and available antidotes can be one of the solutions for the problem of pesticide toxicity for pollinators. We studied the properties of the thiazine dye Methylene blue (MB) as an antidote against the toxic action of pesticides in the bumble bee mitochondria and found that MB stimulated mitochondrial respiration mediated by Complex I of the electron transport chain (ETC) and increased respiration of the mitochondria treated with mitochondria-targeted (chlorfenapyr, hydramethylnon, pyridaben, tolfenpyrad, and fenazaquin) and non-mitochondrial (deltamethrin, metribuzin, and penconazole) pesticides. MB also restored the mitochondrial membrane potential dissipated by the pesticides affecting the ETC. The mechanism of MB action is most probably related to its ability to shunt electron flow in the mitochondrial ETC.
format	article
author	Mikhail Syromyatnikov Ekaterina Nesterova Tatiana Smirnova Vasily Popov
author_facet	Mikhail Syromyatnikov Ekaterina Nesterova Tatiana Smirnova Vasily Popov
author_sort	Mikhail Syromyatnikov
title	Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
title_short	Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
title_full	Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
title_fullStr	Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
title_full_unstemmed	Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
title_sort	methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f4b3579ce124b37a527810979339946
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_version_	1718383028358610944

Methylene blue can act as an antidote to pesticide poisoning of bumble bee mitochondria

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