Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.

Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in tur...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	B Karina Montero, Wasimuddin, Nina Schwensow, Mark A F Gillingham, Yedidya R Ratovonamana, S Jacques Rakotondranary, Victor Corman, Christian Drosten, Jörg U Ganzhorn, Simone Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2f502c64dd324be4ac4e5cc6232679df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f502c64dd324be4ac4e5cc6232679df
record_format	dspace
spelling	oai:doaj.org-article:2f502c64dd324be4ac4e5cc6232679df2021-12-02T19:59:53ZEvidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.1553-73661553-737410.1371/journal.ppat.1009675https://doaj.org/article/2f502c64dd324be4ac4e5cc6232679df2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009675https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection.B Karina MonteroWasimuddinNina SchwensowMark A F GillinghamYedidya R RatovonamanaS Jacques RakotondranaryVictor CormanChristian DrostenJörg U GanzhornSimone SommerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 11, p e1009675 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 B Karina Montero Wasimuddin Nina Schwensow Mark A F Gillingham Yedidya R Ratovonamana S Jacques Rakotondranary Victor Corman Christian Drosten Jörg U Ganzhorn Simone Sommer Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
description	Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection.
format	article
author	B Karina Montero Wasimuddin Nina Schwensow Mark A F Gillingham Yedidya R Ratovonamana S Jacques Rakotondranary Victor Corman Christian Drosten Jörg U Ganzhorn Simone Sommer
author_facet	B Karina Montero Wasimuddin Nina Schwensow Mark A F Gillingham Yedidya R Ratovonamana S Jacques Rakotondranary Victor Corman Christian Drosten Jörg U Ganzhorn Simone Sommer
author_sort	B Karina Montero
title	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
title_short	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
title_full	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
title_fullStr	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
title_full_unstemmed	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.
title_sort	evidence of mhc class i and ii influencing viral and helminth infection via the microbiome in a non-human primate.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2f502c64dd324be4ac4e5cc6232679df
work_keys_str_mv	AT bkarinamontero evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT wasimuddin evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT ninaschwensow evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT markafgillingham evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT yedidyarratovonamana evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT sjacquesrakotondranary evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT victorcorman evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT christiandrosten evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT jorguganzhorn evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate AT simonesommer evidenceofmhcclassiandiiinfluencingviralandhelminthinfectionviathemicrobiomeinanonhumanprimate
_version_	1718375712040157184

Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.

Ejemplares similares