Social rank-associated stress vulnerability predisposes individuals to cocaine attraction

Abstract Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive...

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Autores principales:	Chen Yanovich, Michael L. Kirby, Izhak Michaelevski, Gal Yadid, Albert Pinhasov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f5105ffb1a1437aabf7aa81d8c00a0e
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spelling	oai:doaj.org-article:2f5105ffb1a1437aabf7aa81d8c00a0e2021-12-02T15:08:26ZSocial rank-associated stress vulnerability predisposes individuals to cocaine attraction10.1038/s41598-018-19816-x2045-2322https://doaj.org/article/2f5105ffb1a1437aabf7aa81d8c00a0e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19816-xhttps://doaj.org/toc/2045-2322Abstract Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate the interaction between environmental stress and inbred predisposition to develop addictive behavior to cocaine. In a Conditioned Place Preference (CPP) paradigm using cocaine, Sub mice displayed an aversion to drug, whereas Dom mice displayed drug attraction. Following a 4-week regimen of Chronic Mild Stress (CMS), Sub mice in CPP displayed a marked increase (>400%) in cocaine attraction, whereas Dom mice did not differ in attraction from their non-stressed state. Examination of hippocampal gene expression revealed in Sub mice, exposure to external stimuli, stress or cocaine, increased CRH expression (>100%), which was evoked in Dom mice only by cocaine exposure. Further, stress-induced decreases in DRD1 (>60%) and DRD2 (>50%) expression in Sub mice differed markedly from a complete lack of change in Dom mice. From our findings, we propose that social stratification dictates vulnerability to stress-induced attraction that may lead to addiction via differential regulation of hippocampal response to dopaminergic input, which in turn may influence differing tendency to develop addictive behaviors.Chen YanovichMichael L. KirbyIzhak MichaelevskiGal YadidAlbert PinhasovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen Yanovich Michael L. Kirby Izhak Michaelevski Gal Yadid Albert Pinhasov Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
description	Abstract Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate the interaction between environmental stress and inbred predisposition to develop addictive behavior to cocaine. In a Conditioned Place Preference (CPP) paradigm using cocaine, Sub mice displayed an aversion to drug, whereas Dom mice displayed drug attraction. Following a 4-week regimen of Chronic Mild Stress (CMS), Sub mice in CPP displayed a marked increase (>400%) in cocaine attraction, whereas Dom mice did not differ in attraction from their non-stressed state. Examination of hippocampal gene expression revealed in Sub mice, exposure to external stimuli, stress or cocaine, increased CRH expression (>100%), which was evoked in Dom mice only by cocaine exposure. Further, stress-induced decreases in DRD1 (>60%) and DRD2 (>50%) expression in Sub mice differed markedly from a complete lack of change in Dom mice. From our findings, we propose that social stratification dictates vulnerability to stress-induced attraction that may lead to addiction via differential regulation of hippocampal response to dopaminergic input, which in turn may influence differing tendency to develop addictive behaviors.
format	article
author	Chen Yanovich Michael L. Kirby Izhak Michaelevski Gal Yadid Albert Pinhasov
author_facet	Chen Yanovich Michael L. Kirby Izhak Michaelevski Gal Yadid Albert Pinhasov
author_sort	Chen Yanovich
title	Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
title_short	Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
title_full	Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
title_fullStr	Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
title_full_unstemmed	Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
title_sort	social rank-associated stress vulnerability predisposes individuals to cocaine attraction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2f5105ffb1a1437aabf7aa81d8c00a0e
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Social rank-associated stress vulnerability predisposes individuals to cocaine attraction

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