A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes

A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes

Mimicking enzyme function and improving upon it is a challenge facing nanotechnology. Here the authors design a DNA nanostructure that catalyzes the transport of lipids between bilayers at a rate three orders of magnitude higher than biological enzymes.

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Autores principales: Alexander Ohmann, Chen-Yu Li, Christopher Maffeo, Kareem Al Nahas, Kevin N. Baumann, Kerstin Göpfrich, Jejoong Yoo, Ulrich F. Keyser, Aleksei Aksimentiev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2f5231c7aff4488f9f6fa528592e67b0
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spelling oai:doaj.org-article:2f5231c7aff4488f9f6fa528592e67b02021-12-02T16:49:55ZA synthetic enzyme built from DNA flips 107 lipids per second in biological membranes10.1038/s41467-018-04821-52041-1723https://doaj.org/article/2f5231c7aff4488f9f6fa528592e67b02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04821-5https://doaj.org/toc/2041-1723Mimicking enzyme function and improving upon it is a challenge facing nanotechnology. Here the authors design a DNA nanostructure that catalyzes the transport of lipids between bilayers at a rate three orders of magnitude higher than biological enzymes.Alexander OhmannChen-Yu LiChristopher MaffeoKareem Al NahasKevin N. BaumannKerstin GöpfrichJejoong YooUlrich F. KeyserAleksei AksimentievNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alexander Ohmann
Chen-Yu Li
Christopher Maffeo
Kareem Al Nahas
Kevin N. Baumann
Kerstin Göpfrich
Jejoong Yoo
Ulrich F. Keyser
Aleksei Aksimentiev
A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
description Mimicking enzyme function and improving upon it is a challenge facing nanotechnology. Here the authors design a DNA nanostructure that catalyzes the transport of lipids between bilayers at a rate three orders of magnitude higher than biological enzymes.
format article
author Alexander Ohmann
Chen-Yu Li
Christopher Maffeo
Kareem Al Nahas
Kevin N. Baumann
Kerstin Göpfrich
Jejoong Yoo
Ulrich F. Keyser
Aleksei Aksimentiev
author_facet Alexander Ohmann
Chen-Yu Li
Christopher Maffeo
Kareem Al Nahas
Kevin N. Baumann
Kerstin Göpfrich
Jejoong Yoo
Ulrich F. Keyser
Aleksei Aksimentiev
author_sort Alexander Ohmann
title A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
title_short A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
title_full A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
title_fullStr A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
title_full_unstemmed A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
title_sort synthetic enzyme built from dna flips 107 lipids per second in biological membranes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2f5231c7aff4488f9f6fa528592e67b0
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