Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing

High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose prod...

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Autores principales:	Helen J. Dranse, T. M. Zaved Waise, Sophie C. Hamr, Paige V. Bauer, Mona A. Abraham, Brittany A. Rasmussen, Tony K. T. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2f568c4cce01458e9f67dd6472addf49
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spelling	oai:doaj.org-article:2f568c4cce01458e9f67dd6472addf492021-12-02T16:49:54ZPhysiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing10.1038/s41467-018-03490-82041-1723https://doaj.org/article/2f568c4cce01458e9f67dd6472addf492018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03490-8https://doaj.org/toc/2041-1723High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose production.Helen J. DranseT. M. Zaved WaiseSophie C. HamrPaige V. BauerMona A. AbrahamBrittany A. RasmussenTony K. T. LamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helen J. Dranse T. M. Zaved Waise Sophie C. Hamr Paige V. Bauer Mona A. Abraham Brittany A. Rasmussen Tony K. T. Lam Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
description	High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose production.
format	article
author	Helen J. Dranse T. M. Zaved Waise Sophie C. Hamr Paige V. Bauer Mona A. Abraham Brittany A. Rasmussen Tony K. T. Lam
author_facet	Helen J. Dranse T. M. Zaved Waise Sophie C. Hamr Paige V. Bauer Mona A. Abraham Brittany A. Rasmussen Tony K. T. Lam
author_sort	Helen J. Dranse
title	Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
title_short	Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
title_full	Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
title_fullStr	Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
title_full_unstemmed	Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
title_sort	physiological and therapeutic regulation of glucose homeostasis by upper small intestinal pept1-mediated protein sensing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2f568c4cce01458e9f67dd6472addf49
work_keys_str_mv	AT helenjdranse physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT tmzavedwaise physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT sophiechamr physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT paigevbauer physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT monaaabraham physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT brittanyarasmussen physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing AT tonyktlam physiologicalandtherapeuticregulationofglucosehomeostasisbyuppersmallintestinalpept1mediatedproteinsensing
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Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing

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