White matter abnormalities in adults with bipolar disorder type-II and unipolar depression

Abstract Discerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthre...

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Autores principales:	Anna Manelis, Adriane Soehner, Yaroslav O. Halchenko, Skye Satz, Rachel Ragozzino, Mora Lucero, Holly A. Swartz, Mary L. Phillips, Amelia Versace
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2f573187bb5045e4ac4d0854ca9a376a
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spelling	oai:doaj.org-article:2f573187bb5045e4ac4d0854ca9a376a2021-12-02T14:37:29ZWhite matter abnormalities in adults with bipolar disorder type-II and unipolar depression10.1038/s41598-021-87069-22045-2322https://doaj.org/article/2f573187bb5045e4ac4d0854ca9a376a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87069-2https://doaj.org/toc/2045-2322Abstract Discerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthreshold hypomanic symptoms such as elevated mood, irritability, and increased activity. Previous studies linked bipolar disorder to widespread white matter abnormalities. However, no published work has compared white matter microstructure in individuals with BD-II vs. UD vs. healthy controls (HC), or examined the relationship between spectrum (dimensional) measures of hypomania and white matter microstructure across those individuals. This study aimed to examine fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) across BD-II, UD, and HC groups in the white matter tracts identified by the XTRACT tool in FSL. Individuals with BD-II (n = 18), UD (n = 23), and HC (n = 24) underwent Diffusion Weighted Imaging. The categorical approach revealed decreased FA and increased RD in BD-II and UD vs. HC across multiple tracts. While BD-II had significantly lower FA and higher RD values than UD in the anterior part of the left arcuate fasciculus, UD had significantly lower FA and higher RD values than BD-II in the area of intersections between the right arcuate, inferior fronto-occipital and uncinate fasciculi and forceps minor. The dimensional approach revealed the depression-by-spectrum mania interaction effect on the FA, RD, and AD values in the area of intersection between the right posterior arcuate and middle longitudinal fasciculi. We propose that the white matter microstructure in these tracts reflects a unique pathophysiologic signature and compensatory mechanisms distinguishing BD-II from UD.Anna ManelisAdriane SoehnerYaroslav O. HalchenkoSkye SatzRachel RagozzinoMora LuceroHolly A. SwartzMary L. PhillipsAmelia VersaceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Manelis Adriane Soehner Yaroslav O. Halchenko Skye Satz Rachel Ragozzino Mora Lucero Holly A. Swartz Mary L. Phillips Amelia Versace White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
description	Abstract Discerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthreshold hypomanic symptoms such as elevated mood, irritability, and increased activity. Previous studies linked bipolar disorder to widespread white matter abnormalities. However, no published work has compared white matter microstructure in individuals with BD-II vs. UD vs. healthy controls (HC), or examined the relationship between spectrum (dimensional) measures of hypomania and white matter microstructure across those individuals. This study aimed to examine fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) across BD-II, UD, and HC groups in the white matter tracts identified by the XTRACT tool in FSL. Individuals with BD-II (n = 18), UD (n = 23), and HC (n = 24) underwent Diffusion Weighted Imaging. The categorical approach revealed decreased FA and increased RD in BD-II and UD vs. HC across multiple tracts. While BD-II had significantly lower FA and higher RD values than UD in the anterior part of the left arcuate fasciculus, UD had significantly lower FA and higher RD values than BD-II in the area of intersections between the right arcuate, inferior fronto-occipital and uncinate fasciculi and forceps minor. The dimensional approach revealed the depression-by-spectrum mania interaction effect on the FA, RD, and AD values in the area of intersection between the right posterior arcuate and middle longitudinal fasciculi. We propose that the white matter microstructure in these tracts reflects a unique pathophysiologic signature and compensatory mechanisms distinguishing BD-II from UD.
format	article
author	Anna Manelis Adriane Soehner Yaroslav O. Halchenko Skye Satz Rachel Ragozzino Mora Lucero Holly A. Swartz Mary L. Phillips Amelia Versace
author_facet	Anna Manelis Adriane Soehner Yaroslav O. Halchenko Skye Satz Rachel Ragozzino Mora Lucero Holly A. Swartz Mary L. Phillips Amelia Versace
author_sort	Anna Manelis
title	White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
title_short	White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
title_full	White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
title_fullStr	White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
title_full_unstemmed	White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
title_sort	white matter abnormalities in adults with bipolar disorder type-ii and unipolar depression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f573187bb5045e4ac4d0854ca9a376a
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White matter abnormalities in adults with bipolar disorder type-II and unipolar depression

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