Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years
Abstract Background Although some kinds of endoluminal surgery for patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have been reported, there are few reports on their long-term outcomes. In 2014, we reported the effectiveness of endoscopic surgery for PPI-r...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
BMC
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2f58b9c5b2b041ff9673ce2a7bb39ab3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2f58b9c5b2b041ff9673ce2a7bb39ab3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2f58b9c5b2b041ff9673ce2a7bb39ab32021-11-21T12:15:41ZOutcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years10.1186/s12876-021-02022-x1471-230Xhttps://doaj.org/article/2f58b9c5b2b041ff9673ce2a7bb39ab32021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02022-xhttps://doaj.org/toc/1471-230XAbstract Background Although some kinds of endoluminal surgery for patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have been reported, there are few reports on their long-term outcomes. In 2014, we reported the effectiveness of endoscopic surgery for PPI-refractory GERD, which we invented and named endoscopic submucosal dissection for GERD (ESD-G) in 2008. Thereafter, we accumulated more cases and monitored the patients’ condition postoperatively and describe the outcomes herein. Patients and methods This single-center, single-arm trial was conducted at the Osaka Medical and Pharmaceutical University Hospital. We compared outcomes between before and 3–6 months after ESD-G. Additionally, we investigated the outcomes of patients 5 or more years after ESD-G. Results We performed 42 ESD-G procedures in 35 patients between 2008 and 2020. In seven patients, ESD-G was performed twice for various reasons. The frequency scale for the symptoms of GERD score was significantly improved 3–6 months after ESD-G (22 → 10, p < 0.0001); the Los Angeles classification for reflux esophagitis was clearly improved after ESD-G (p = 0.0423). The number of reflux episodes was not decreased by ESD-G. There was a significant difference in the potency unit of gastric acid secretion suppressants for controlling GERD-related symptoms between baseline and 3–6 months after ESD-G (p = 0.0009). In patients without a history of distal gastrectomy who underwent ESD-G, the potency unit of gastric acid secretion suppressants significantly decreased 5 or more years after ESD-G (p = 0.0121). Conclusion ESD-G may be effective in patients with refractory GERD-related symptoms without a history of distal gastrectomy.Kazuhiro OtaToshihisa TakeuchiYuichi KojimaNoriaki SugawaraShinya NishidaTaro IwatsuboShimpei KawaguchiSatoshi HaradaSatoshi TokiokaKazuhide HiguchiBMCarticleEndoscopic surgeryProton pump inhibitorGastroesohageal reflux diseaseESD-GDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Endoscopic surgery Proton pump inhibitor Gastroesohageal reflux disease ESD-G Diseases of the digestive system. Gastroenterology RC799-869 |
| spellingShingle |
Endoscopic surgery Proton pump inhibitor Gastroesohageal reflux disease ESD-G Diseases of the digestive system. Gastroenterology RC799-869 Kazuhiro Ota Toshihisa Takeuchi Yuichi Kojima Noriaki Sugawara Shinya Nishida Taro Iwatsubo Shimpei Kawaguchi Satoshi Harada Satoshi Tokioka Kazuhide Higuchi Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| description |
Abstract Background Although some kinds of endoluminal surgery for patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have been reported, there are few reports on their long-term outcomes. In 2014, we reported the effectiveness of endoscopic surgery for PPI-refractory GERD, which we invented and named endoscopic submucosal dissection for GERD (ESD-G) in 2008. Thereafter, we accumulated more cases and monitored the patients’ condition postoperatively and describe the outcomes herein. Patients and methods This single-center, single-arm trial was conducted at the Osaka Medical and Pharmaceutical University Hospital. We compared outcomes between before and 3–6 months after ESD-G. Additionally, we investigated the outcomes of patients 5 or more years after ESD-G. Results We performed 42 ESD-G procedures in 35 patients between 2008 and 2020. In seven patients, ESD-G was performed twice for various reasons. The frequency scale for the symptoms of GERD score was significantly improved 3–6 months after ESD-G (22 → 10, p < 0.0001); the Los Angeles classification for reflux esophagitis was clearly improved after ESD-G (p = 0.0423). The number of reflux episodes was not decreased by ESD-G. There was a significant difference in the potency unit of gastric acid secretion suppressants for controlling GERD-related symptoms between baseline and 3–6 months after ESD-G (p = 0.0009). In patients without a history of distal gastrectomy who underwent ESD-G, the potency unit of gastric acid secretion suppressants significantly decreased 5 or more years after ESD-G (p = 0.0121). Conclusion ESD-G may be effective in patients with refractory GERD-related symptoms without a history of distal gastrectomy. |
| format |
article |
| author |
Kazuhiro Ota Toshihisa Takeuchi Yuichi Kojima Noriaki Sugawara Shinya Nishida Taro Iwatsubo Shimpei Kawaguchi Satoshi Harada Satoshi Tokioka Kazuhide Higuchi |
| author_facet |
Kazuhiro Ota Toshihisa Takeuchi Yuichi Kojima Noriaki Sugawara Shinya Nishida Taro Iwatsubo Shimpei Kawaguchi Satoshi Harada Satoshi Tokioka Kazuhide Higuchi |
| author_sort |
Kazuhiro Ota |
| title |
Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| title_short |
Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| title_full |
Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| title_fullStr |
Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| title_full_unstemmed |
Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years |
| title_sort |
outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (esd-g) for medication-refractory gastroesophageal reflux disease: 35 cases underwent esd-g including 15 cases followed more than 5 years |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/2f58b9c5b2b041ff9673ce2a7bb39ab3 |
| work_keys_str_mv |
AT kazuhiroota outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT toshihisatakeuchi outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT yuichikojima outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT noriakisugawara outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT shinyanishida outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT taroiwatsubo outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT shimpeikawaguchi outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT satoshiharada outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT satoshitokioka outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years AT kazuhidehiguchi outcomesofendoscopicsubmucosaldissectionforgastroesophagealrefluxdiseaseesdgformedicationrefractorygastroesophagealrefluxdisease35casesunderwentesdgincluding15casesfollowedmorethan5years |
| _version_ |
1718419115498012672 |