pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

Yiwen Wang,* Fei Qin,* Haina Tan, Yan Zhang, Miao Jiang, Mei Lu, Xin Yao School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Carboxymethyl-&bet...

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Autores principales: Wang Y, Qin F, Tan H, Zhang Y, Jiang M, Lu M, Yao X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
natural antineoplastic drugs
chitosan-tripolyphosphate
nanoparticles
pH-sensitive release
controlled-releasing potential
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/2f5ba908b5c5432f8307b6493a96102b
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spelling oai:doaj.org-article:2f5ba908b5c5432f8307b6493a96102b2021-12-02T03:11:39ZpH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs1178-2013https://doaj.org/article/2f5ba908b5c5432f8307b6493a96102b2015-12-01T00:00:00Zhttps://www.dovepress.com/ph-responsive-glycol-chitosan-cross-linked-carboxymethyl-beta-cyclodex-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yiwen Wang,* Fei Qin,* Haina Tan, Yan Zhang, Miao Jiang, Mei Lu, Xin Yao School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Carboxymethyl-β-cyclodextrin (CMβ-CD)-modified glycol chitosan (GCS) nanoparticles (GCS-CMβ-CD NPs) were synthesized, and their pH-sensitive drug-release properties were investigated. GCS-CMβ-CD NPs could encapsulate doxorubicin hydrochloride (DOX), and the encapsulation efficiency and loading capacity increased with the amount of CMβ-CD. Drug-release studies indicate that DOX released was greater in acidic medium (pH 5.0) than in weakly basic medium (pH 7.4). The mechanism underlying the pH-sensitive properties of the carrier was analyzed. Finally, the MCF-7 (human breast cancer) and SW480 cell lines (human colon cancer) were used to evaluate the cytotoxicity of the NPs. The drug-loaded carriers show good inhibition of the growth of cancer cells compared with free DOX, and the carriers have good biocompatibility. In addition, the drug-loaded NPs have sustained drug-release properties. All these properties of the newly synthesized GCS-CMβ-CD NPs suggest a promising potential as an effective anticancer drug-delivery system for controlled drug release. Keywords: MCF-7, SW480, surface plasmon resonance, encapsulation efficiency, loading capacity, cell viabilityWang YQin FTan HZhang YJiang MLu MYao XDove Medical Pressarticlenatural antineoplastic drugschitosan-tripolyphosphatenanoparticlespH-sensitive releasecontrolled-releasing potentialMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 7359-7370 (2015)
institution DOAJ
collection DOAJ
language EN
topic natural antineoplastic drugs
chitosan-tripolyphosphate
nanoparticles
pH-sensitive release
controlled-releasing potential
Medicine (General)
R5-920
spellingShingle natural antineoplastic drugs
chitosan-tripolyphosphate
nanoparticles
pH-sensitive release
controlled-releasing potential
Medicine (General)
R5-920
Wang Y
Qin F
Tan H
Zhang Y
Jiang M
Lu M
Yao X
pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
description Yiwen Wang,* Fei Qin,* Haina Tan, Yan Zhang, Miao Jiang, Mei Lu, Xin Yao School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Carboxymethyl-β-cyclodextrin (CMβ-CD)-modified glycol chitosan (GCS) nanoparticles (GCS-CMβ-CD NPs) were synthesized, and their pH-sensitive drug-release properties were investigated. GCS-CMβ-CD NPs could encapsulate doxorubicin hydrochloride (DOX), and the encapsulation efficiency and loading capacity increased with the amount of CMβ-CD. Drug-release studies indicate that DOX released was greater in acidic medium (pH 5.0) than in weakly basic medium (pH 7.4). The mechanism underlying the pH-sensitive properties of the carrier was analyzed. Finally, the MCF-7 (human breast cancer) and SW480 cell lines (human colon cancer) were used to evaluate the cytotoxicity of the NPs. The drug-loaded carriers show good inhibition of the growth of cancer cells compared with free DOX, and the carriers have good biocompatibility. In addition, the drug-loaded NPs have sustained drug-release properties. All these properties of the newly synthesized GCS-CMβ-CD NPs suggest a promising potential as an effective anticancer drug-delivery system for controlled drug release. Keywords: MCF-7, SW480, surface plasmon resonance, encapsulation efficiency, loading capacity, cell viability
format article
author Wang Y
Qin F
Tan H
Zhang Y
Jiang M
Lu M
Yao X
author_facet Wang Y
Qin F
Tan H
Zhang Y
Jiang M
Lu M
Yao X
author_sort Wang Y
title pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
title_short pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
title_full pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
title_fullStr pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
title_full_unstemmed pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
title_sort ph-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/2f5ba908b5c5432f8307b6493a96102b
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