Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice

Zemene Demelash Kifle,1 Yaschilal Muche Belayneh2 1Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespondence: Zeme...

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Autores principales:	Kifle ZD, Belayneh YM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hagenia abyssinica diabetes mellitus streptozotocin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2f5e0219c6e94f94bba2e5dd461107ee
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spelling	oai:doaj.org-article:2f5e0219c6e94f94bba2e5dd461107ee2021-12-02T12:31:39ZAntidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice1178-7007https://doaj.org/article/2f5e0219c6e94f94bba2e5dd461107ee2020-10-01T00:00:00Zhttps://www.dovepress.com/antidiabetic-and-anti-hyperlipidemic-effects-of-the-crude-hydromethano-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Zemene Demelash Kifle,1 Yaschilal Muche Belayneh2 1Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespondence: Zemene Demelash KifleDepartment of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar 196, EthiopiaTel +251918026724Email zeme2010@gmail.comBackground: The leaves of Hagenia abyssinica (Rosaceae) have been used traditionally for the management of diabetes mellitus. Thus, this study aimed to evaluate the antidiabetic and anti-hyperlipidemic activity of Hagenia abyssinica leaves crude extract in streptozotocin-induced diabetic mice.Methods: Antidiabetic and anti-hyperlipidemic activity of the crude extract of Hagenia abyssinica was studied in streptozotocin-induced diabetic mice. The effects of the extract on fasting blood glucose level, body weight, and serum lipid profiles were analyzed. One-way ANOVA followed by Tukey’s post hoc test was used for data analysis and p< 0.05 was considered as statistically significant.Results: Hagenia abyssinica leaves crude extract showed significant (p< 0.05-p< 0.001) blood-glucose-lowering activity. Moreover, the crude extract of H. abyssinica reduced the fasting blood glucose level by 23.21%, 38.20%, 43.53%, and 58.99%, respectively, for CE100, CE 200, CE 400, and GLC 5 mg/kg on the 14th day of treatment. After diabetic mice were treated with H. abyssinica (100, 200 and 400 mg/kg) for 14 days, there was a significant decrease in serum total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and serum triglyceride and a significant increase in body weight, and HDL-cholesterol level as compared to diabetic control.Conclusion: The present findings revealed that H. abyssinica leaves could be useful for the management of diabetes mellitus and other abnormalities related to this metabolic disorder. Thus, the present study may support the traditional use of H. abyssinica for diabetes mellitus treatment.Keywords: Hagenia abyssinica, diabetes mellitus, streptozotocinKifle ZDBelayneh YMDove Medical Pressarticlehagenia abyssinicadiabetes mellitusstreptozotocinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4085-4094 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hagenia abyssinica diabetes mellitus streptozotocin Specialties of internal medicine RC581-951
spellingShingle	hagenia abyssinica diabetes mellitus streptozotocin Specialties of internal medicine RC581-951 Kifle ZD Belayneh YM Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
description	Zemene Demelash Kifle,1 Yaschilal Muche Belayneh2 1Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, EthiopiaCorrespondence: Zemene Demelash KifleDepartment of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar 196, EthiopiaTel +251918026724Email zeme2010@gmail.comBackground: The leaves of Hagenia abyssinica (Rosaceae) have been used traditionally for the management of diabetes mellitus. Thus, this study aimed to evaluate the antidiabetic and anti-hyperlipidemic activity of Hagenia abyssinica leaves crude extract in streptozotocin-induced diabetic mice.Methods: Antidiabetic and anti-hyperlipidemic activity of the crude extract of Hagenia abyssinica was studied in streptozotocin-induced diabetic mice. The effects of the extract on fasting blood glucose level, body weight, and serum lipid profiles were analyzed. One-way ANOVA followed by Tukey’s post hoc test was used for data analysis and p< 0.05 was considered as statistically significant.Results: Hagenia abyssinica leaves crude extract showed significant (p< 0.05-p< 0.001) blood-glucose-lowering activity. Moreover, the crude extract of H. abyssinica reduced the fasting blood glucose level by 23.21%, 38.20%, 43.53%, and 58.99%, respectively, for CE100, CE 200, CE 400, and GLC 5 mg/kg on the 14th day of treatment. After diabetic mice were treated with H. abyssinica (100, 200 and 400 mg/kg) for 14 days, there was a significant decrease in serum total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and serum triglyceride and a significant increase in body weight, and HDL-cholesterol level as compared to diabetic control.Conclusion: The present findings revealed that H. abyssinica leaves could be useful for the management of diabetes mellitus and other abnormalities related to this metabolic disorder. Thus, the present study may support the traditional use of H. abyssinica for diabetes mellitus treatment.Keywords: Hagenia abyssinica, diabetes mellitus, streptozotocin
format	article
author	Kifle ZD Belayneh YM
author_facet	Kifle ZD Belayneh YM
author_sort	Kifle ZD
title	Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
title_short	Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
title_full	Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
title_fullStr	Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
title_full_unstemmed	Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice
title_sort	antidiabetic and anti-hyperlipidemic effects of the crude hydromethanol extract of hagenia abyssinica (rosaceae) leaves in streptozotocin-induced diabetic mice
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2f5e0219c6e94f94bba2e5dd461107ee
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Antidiabetic and Anti-hyperlipidemic Effects of the Crude Hydromethanol Extract of Hagenia abyssinica (Rosaceae) Leaves in Streptozotocin-Induced Diabetic Mice

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