Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.

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Autores principales:	Milton Guilherme Forestieri Fernandes, Julia Xiao Xuan Luo, Qiao-Ling Cui, Kelly Perlman, Florian Pernin, Moein Yaqubi, Jeffery A. Hall, Roy Dudley, Myriam Srour, Charles P. Couturier, Kevin Petrecca, Catherine Larochelle, Luke M. Healy, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2f5ecb99de5f4c29b216220d02b72b5a
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spelling	oai:doaj.org-article:2f5ecb99de5f4c29b216220d02b72b5a2021-12-02T15:13:16ZAge-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways10.1038/s42003-020-01557-12399-3642https://doaj.org/article/2f5ecb99de5f4c29b216220d02b72b5a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01557-1https://doaj.org/toc/2399-3642Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.Milton Guilherme Forestieri FernandesJulia Xiao Xuan LuoQiao-Ling CuiKelly PerlmanFlorian PerninMoein YaqubiJeffery A. HallRoy DudleyMyriam SrourCharles P. CouturierKevin PetreccaCatherine LarochelleLuke M. HealyJo Anne StrattonTimothy E. KennedyJack P. AntelNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Milton Guilherme Forestieri Fernandes Julia Xiao Xuan Luo Qiao-Ling Cui Kelly Perlman Florian Pernin Moein Yaqubi Jeffery A. Hall Roy Dudley Myriam Srour Charles P. Couturier Kevin Petrecca Catherine Larochelle Luke M. Healy Jo Anne Stratton Timothy E. Kennedy Jack P. Antel Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
description	Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.
format	article
author	Milton Guilherme Forestieri Fernandes Julia Xiao Xuan Luo Qiao-Ling Cui Kelly Perlman Florian Pernin Moein Yaqubi Jeffery A. Hall Roy Dudley Myriam Srour Charles P. Couturier Kevin Petrecca Catherine Larochelle Luke M. Healy Jo Anne Stratton Timothy E. Kennedy Jack P. Antel
author_facet	Milton Guilherme Forestieri Fernandes Julia Xiao Xuan Luo Qiao-Ling Cui Kelly Perlman Florian Pernin Moein Yaqubi Jeffery A. Hall Roy Dudley Myriam Srour Charles P. Couturier Kevin Petrecca Catherine Larochelle Luke M. Healy Jo Anne Stratton Timothy E. Kennedy Jack P. Antel
author_sort	Milton Guilherme Forestieri Fernandes
title	Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
title_short	Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
title_full	Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
title_fullStr	Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
title_full_unstemmed	Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
title_sort	age-related injury responses of human oligodendrocytes to metabolic insults: link to bcl-2 and autophagy pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2f5ecb99de5f4c29b216220d02b72b5a
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Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

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