APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

ApoE is a member of lipoprotein family. It is the most common lipoprotein in the central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes and macrophages. According to recent data, it has endotheliotropic and immunomodulator...

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Autores principales:	I. K. Malashenkova, S. A. Krynskiy, M. V. Mamoshina, N. A. Didkovskiy
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	amyloid-beta alzheimer’s disease inflammation immune response neurodegeneration apoe Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2f62889f11144b0ea39a508313b3982e
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spelling	oai:doaj.org-article:2f62889f11144b0ea39a508313b3982e2021-11-18T08:03:47ZAPOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE1563-06252313-741X10.15789/1563-0625-2018-3-303-312https://doaj.org/article/2f62889f11144b0ea39a508313b3982e2018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1543https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XApoE is a member of lipoprotein family. It is the most common lipoprotein in the central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes and macrophages. According to recent data, it has endotheliotropic and immunomodulatory functions, regulating inflammatory activation of mononuclear phagocytes and antigen-induced lymphocyte proliferation. APOE4 allele is a major genetic risk factor of Alzheimer’s disease, with prevalence 3-12 times higher in those who have this allele. Mechanisms that predispose carriers of the allele to earlier clinical presentation of neurodegeneration include changes in lipid metabolism in the CNS, in the buildup of neurotoxic amyloid-beta oligomers, in the clearance of amyloid-beta peptides from the CNS and in regulation of immune response. In this review the functions of ApoE protein in central nervous and immune system and changes in functional activity of the protein in APOE4 carriers are discussed. The impact of APOE4 allele on monocyte phenotype and inflammatory activation of monocytes, on specific cell-mediated immune response to amyloid-beta antigens and on effectiveness of immunomodulatory therapy in patients with Alzheimer’s disease summarized, as well as the possible role of changes in the immune response characteristic for APOE4 carriers in the increased risk of Alzheimer’s disease.I. K. MalashenkovaS. A. KrynskiyM. V. MamoshinaN. A. DidkovskiySPb RAACIarticleamyloid-betaalzheimer’s diseaseinflammationimmune responseneurodegenerationapoeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 3, Pp 303-312 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	amyloid-beta alzheimer’s disease inflammation immune response neurodegeneration apoe Immunologic diseases. Allergy RC581-607
spellingShingle	amyloid-beta alzheimer’s disease inflammation immune response neurodegeneration apoe Immunologic diseases. Allergy RC581-607 I. K. Malashenkova S. A. Krynskiy M. V. Mamoshina N. A. Didkovskiy APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
description	ApoE is a member of lipoprotein family. It is the most common lipoprotein in the central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes and macrophages. According to recent data, it has endotheliotropic and immunomodulatory functions, regulating inflammatory activation of mononuclear phagocytes and antigen-induced lymphocyte proliferation. APOE4 allele is a major genetic risk factor of Alzheimer’s disease, with prevalence 3-12 times higher in those who have this allele. Mechanisms that predispose carriers of the allele to earlier clinical presentation of neurodegeneration include changes in lipid metabolism in the CNS, in the buildup of neurotoxic amyloid-beta oligomers, in the clearance of amyloid-beta peptides from the CNS and in regulation of immune response. In this review the functions of ApoE protein in central nervous and immune system and changes in functional activity of the protein in APOE4 carriers are discussed. The impact of APOE4 allele on monocyte phenotype and inflammatory activation of monocytes, on specific cell-mediated immune response to amyloid-beta antigens and on effectiveness of immunomodulatory therapy in patients with Alzheimer’s disease summarized, as well as the possible role of changes in the immune response characteristic for APOE4 carriers in the increased risk of Alzheimer’s disease.
format	article
author	I. K. Malashenkova S. A. Krynskiy M. V. Mamoshina N. A. Didkovskiy
author_facet	I. K. Malashenkova S. A. Krynskiy M. V. Mamoshina N. A. Didkovskiy
author_sort	I. K. Malashenkova
title	APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
title_short	APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
title_full	APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
title_fullStr	APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
title_full_unstemmed	APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
title_sort	apoe gene polymorphism: the impact of apoe4 allele on systemic inflammation and its role in the pathogenesis of alzheimer’s disease
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/2f62889f11144b0ea39a508313b3982e
work_keys_str_mv	AT ikmalashenkova apoegenepolymorphismtheimpactofapoe4alleleonsystemicinflammationanditsroleinthepathogenesisofalzheimersdisease AT sakrynskiy apoegenepolymorphismtheimpactofapoe4alleleonsystemicinflammationanditsroleinthepathogenesisofalzheimersdisease AT mvmamoshina apoegenepolymorphismtheimpactofapoe4alleleonsystemicinflammationanditsroleinthepathogenesisofalzheimersdisease AT nadidkovskiy apoegenepolymorphismtheimpactofapoe4alleleonsystemicinflammationanditsroleinthepathogenesisofalzheimersdisease
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APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

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