Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex

Alexandros Takis,1 Dimitrios Alonistiotis,1 Dimitrios Panagiotidis,1 Nikolaos Ioannou,1 Dimitris Papaconstantinou,2 Panagiotis Theodossiadis1 1Ophthalmological University Clinic of Athens, Attikon Hospital, Athens, Greece; 2Ophthalmological University Clinic of Athens, Geniko Kratiko Hospital, Athe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takis A, Alonistiotis D, Panagiotidis D, Ioannou N, Papaconstantinou D, Theodossiadis P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2f669c960b7843548781005839cd8cd4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f669c960b7843548781005839cd8cd4
record_format	dspace
spelling	oai:doaj.org-article:2f669c960b7843548781005839cd8cd42021-12-02T01:15:49ZComparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex1177-5483https://doaj.org/article/2f669c960b7843548781005839cd8cd42014-02-01T00:00:00Zhttp://www.dovepress.com/comparison-of-the-nerve-fiber-layer-of-type-2-diabetic-patients-withou-a15949https://doaj.org/toc/1177-5483 Alexandros Takis,1 Dimitrios Alonistiotis,1 Dimitrios Panagiotidis,1 Nikolaos Ioannou,1 Dimitris Papaconstantinou,2 Panagiotis Theodossiadis1 1Ophthalmological University Clinic of Athens, Attikon Hospital, Athens, Greece; 2Ophthalmological University Clinic of Athens, Geniko Kratiko Hospital, Athens, Greece Background: The retinal nerve fiber layer (RNFL) thickness in patients with diabetes mellitus type 2 was compared to normal subjects of similar age and sex, having first excluded any risk factors for glaucoma. The correlation between the RNFL thickness and the severity of diabetic retinopathy was investigated at its primary stages and with other ocular and diabetic parameters. Methods: A prospective, case series study was carried out. Twenty-seven diabetic patients without diabetic retinopathy, 24 diabetic patients with mild retinopathy, and 25 normal, age-matched subjects underwent a complete ophthalmological examination and imaging with scanning laser polarimetry for the evaluation of the RNFL. Multivariate analysis was applied in order to investigate the correlation between RNFL and diabetic parameters, such as age, duration of diabetes, insulin therapy, levels of glycosylated hemoglobin; and ocular parameters, such as cup to disc ratio, levels of normal intraocular pressure, and central corneal thickness. Results: The mean inferior average of RNFL and the temporal-superior-nasal-inferior-temporal standard deviation were statistically significantly lower in both diabetic groups, and the nerve fiber index was higher (P=0.04) compared to the normal group. There was no statistically significant difference between the diabetic groups. The factor analysis showed no significant correlation between the RNFL and the previously mentioned diabetic and ocular parameters. Conclusion: The existence of diabetes should be seriously considered in evaluating the results of scanning laser polarimetry. Multivariate analysis for RNFL was used for the first time. Keywords: diabetes, glaucoma, RNFL, SLPTakis AAlonistiotis DPanagiotidis DIoannou NPapaconstantinou DTheodossiadis PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 455-463 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Takis A Alonistiotis D Panagiotidis D Ioannou N Papaconstantinou D Theodossiadis P Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
description	Alexandros Takis,1 Dimitrios Alonistiotis,1 Dimitrios Panagiotidis,1 Nikolaos Ioannou,1 Dimitris Papaconstantinou,2 Panagiotis Theodossiadis1 1Ophthalmological University Clinic of Athens, Attikon Hospital, Athens, Greece; 2Ophthalmological University Clinic of Athens, Geniko Kratiko Hospital, Athens, Greece Background: The retinal nerve fiber layer (RNFL) thickness in patients with diabetes mellitus type 2 was compared to normal subjects of similar age and sex, having first excluded any risk factors for glaucoma. The correlation between the RNFL thickness and the severity of diabetic retinopathy was investigated at its primary stages and with other ocular and diabetic parameters. Methods: A prospective, case series study was carried out. Twenty-seven diabetic patients without diabetic retinopathy, 24 diabetic patients with mild retinopathy, and 25 normal, age-matched subjects underwent a complete ophthalmological examination and imaging with scanning laser polarimetry for the evaluation of the RNFL. Multivariate analysis was applied in order to investigate the correlation between RNFL and diabetic parameters, such as age, duration of diabetes, insulin therapy, levels of glycosylated hemoglobin; and ocular parameters, such as cup to disc ratio, levels of normal intraocular pressure, and central corneal thickness. Results: The mean inferior average of RNFL and the temporal-superior-nasal-inferior-temporal standard deviation were statistically significantly lower in both diabetic groups, and the nerve fiber index was higher (P=0.04) compared to the normal group. There was no statistically significant difference between the diabetic groups. The factor analysis showed no significant correlation between the RNFL and the previously mentioned diabetic and ocular parameters. Conclusion: The existence of diabetes should be seriously considered in evaluating the results of scanning laser polarimetry. Multivariate analysis for RNFL was used for the first time. Keywords: diabetes, glaucoma, RNFL, SLP
format	article
author	Takis A Alonistiotis D Panagiotidis D Ioannou N Papaconstantinou D Theodossiadis P
author_facet	Takis A Alonistiotis D Panagiotidis D Ioannou N Papaconstantinou D Theodossiadis P
author_sort	Takis A
title	Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
title_short	Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
title_full	Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
title_fullStr	Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
title_full_unstemmed	Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
title_sort	comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2f669c960b7843548781005839cd8cd4
work_keys_str_mv	AT takisa comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex AT alonistiotisd comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex AT panagiotidisd comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex AT ioannoun comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex AT papaconstantinoud comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex AT theodossiadisp comparisonofthenervefiberlayeroftype2diabeticpatientswithoutglaucomawithnormalsubjectsofthesameageandsex
_version_	1718403191130816512

Comparison of the nerve fiber layer of type 2 diabetic patients without glaucoma with normal subjects of the same age and sex

Ejemplares similares