ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M2-like TAM po...

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Autores principales: Jinlong Yin, Sung Soo Kim, Eunji Choi, Young Taek Oh, Weiwei Lin, Tae-Hoon Kim, Jason K. Sa, Jun Hee Hong, Se Hwan Park, Hyung Joon Kwon, Xiong Jin, Yeonhee You, Ji Hye Kim, Hyunggee Kim, Jaekyoung Son, Jeongwu Lee, Do-Hyun Nam, Kui Son Choi, Bingyang Shi, Ho-Shin Gwak, Heon Yoo, Antonio Iavarone, Jong Heon Kim, Jong Bae Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2f6a1b63b819473598e5e4487f1b7d64
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spelling oai:doaj.org-article:2f6a1b63b819473598e5e4487f1b7d642021-12-02T17:52:29ZARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages10.1038/s41467-020-16789-22041-1723https://doaj.org/article/2f6a1b63b819473598e5e4487f1b7d642020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16789-2https://doaj.org/toc/2041-1723How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M2-like TAM polarization.Jinlong YinSung Soo KimEunji ChoiYoung Taek OhWeiwei LinTae-Hoon KimJason K. SaJun Hee HongSe Hwan ParkHyung Joon KwonXiong JinYeonhee YouJi Hye KimHyunggee KimJaekyoung SonJeongwu LeeDo-Hyun NamKui Son ChoiBingyang ShiHo-Shin GwakHeon YooAntonio IavaroneJong Heon KimJong Bae ParkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinlong Yin
Sung Soo Kim
Eunji Choi
Young Taek Oh
Weiwei Lin
Tae-Hoon Kim
Jason K. Sa
Jun Hee Hong
Se Hwan Park
Hyung Joon Kwon
Xiong Jin
Yeonhee You
Ji Hye Kim
Hyunggee Kim
Jaekyoung Son
Jeongwu Lee
Do-Hyun Nam
Kui Son Choi
Bingyang Shi
Ho-Shin Gwak
Heon Yoo
Antonio Iavarone
Jong Heon Kim
Jong Bae Park
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
description How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M2-like TAM polarization.
format article
author Jinlong Yin
Sung Soo Kim
Eunji Choi
Young Taek Oh
Weiwei Lin
Tae-Hoon Kim
Jason K. Sa
Jun Hee Hong
Se Hwan Park
Hyung Joon Kwon
Xiong Jin
Yeonhee You
Ji Hye Kim
Hyunggee Kim
Jaekyoung Son
Jeongwu Lee
Do-Hyun Nam
Kui Son Choi
Bingyang Shi
Ho-Shin Gwak
Heon Yoo
Antonio Iavarone
Jong Heon Kim
Jong Bae Park
author_facet Jinlong Yin
Sung Soo Kim
Eunji Choi
Young Taek Oh
Weiwei Lin
Tae-Hoon Kim
Jason K. Sa
Jun Hee Hong
Se Hwan Park
Hyung Joon Kwon
Xiong Jin
Yeonhee You
Ji Hye Kim
Hyunggee Kim
Jaekyoung Son
Jeongwu Lee
Do-Hyun Nam
Kui Son Choi
Bingyang Shi
Ho-Shin Gwak
Heon Yoo
Antonio Iavarone
Jong Heon Kim
Jong Bae Park
author_sort Jinlong Yin
title ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
title_short ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
title_full ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
title_fullStr ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
title_full_unstemmed ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
title_sort ars2/magl signaling in glioblastoma stem cells promotes self-renewal and m2-like polarization of tumor-associated macrophages
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2f6a1b63b819473598e5e4487f1b7d64
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