Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A

ABSTRACT As obligate intracellular parasites, viruses are dependent on their infected hosts for survival. Consequently, viruses are under enormous selective pressure to utilize available cellular components and processes to their own advantage. As most, if not all, cellular activities are regulated...

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Autores principales:	Cason R. King, Ali Zhang, Tanner M. Tessier, Steven F. Gameiro, Joe S. Mymryk
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	chromatin E1A hub protein human adenovirus protein-protein interaction transcription Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2f6c2011fd9c404c8566703b333ccfb0
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spelling	oai:doaj.org-article:2f6c2011fd9c404c8566703b333ccfb02021-11-15T16:00:27ZHacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A10.1128/mBio.00390-182150-7511https://doaj.org/article/2f6c2011fd9c404c8566703b333ccfb02018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00390-18https://doaj.org/toc/2150-7511ABSTRACT As obligate intracellular parasites, viruses are dependent on their infected hosts for survival. Consequently, viruses are under enormous selective pressure to utilize available cellular components and processes to their own advantage. As most, if not all, cellular activities are regulated at some level via protein interactions, host protein interaction networks are particularly vulnerable to viral exploitation. Indeed, viral proteins frequently target highly connected “hub” proteins to “hack” the cellular network, defining the molecular basis for viral control over the host. This widespread and successful strategy of network intrusion and exploitation has evolved convergently among numerous genetically distinct viruses as a result of the endless evolutionary arms race between pathogens and hosts. Here we examine the means by which a particularly well-connected viral hub protein, human adenovirus E1A, compromises and exploits the vulnerabilities of eukaryotic protein interaction networks. Importantly, these interactions identify critical regulatory hubs in the human proteome and help define the molecular basis of their function.Cason R. KingAli ZhangTanner M. TessierSteven F. GameiroJoe S. MymrykAmerican Society for MicrobiologyarticlechromatinE1Ahub proteinhuman adenovirusprotein-protein interactiontranscriptionMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chromatin E1A hub protein human adenovirus protein-protein interaction transcription Microbiology QR1-502
spellingShingle	chromatin E1A hub protein human adenovirus protein-protein interaction transcription Microbiology QR1-502 Cason R. King Ali Zhang Tanner M. Tessier Steven F. Gameiro Joe S. Mymryk Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
description	ABSTRACT As obligate intracellular parasites, viruses are dependent on their infected hosts for survival. Consequently, viruses are under enormous selective pressure to utilize available cellular components and processes to their own advantage. As most, if not all, cellular activities are regulated at some level via protein interactions, host protein interaction networks are particularly vulnerable to viral exploitation. Indeed, viral proteins frequently target highly connected “hub” proteins to “hack” the cellular network, defining the molecular basis for viral control over the host. This widespread and successful strategy of network intrusion and exploitation has evolved convergently among numerous genetically distinct viruses as a result of the endless evolutionary arms race between pathogens and hosts. Here we examine the means by which a particularly well-connected viral hub protein, human adenovirus E1A, compromises and exploits the vulnerabilities of eukaryotic protein interaction networks. Importantly, these interactions identify critical regulatory hubs in the human proteome and help define the molecular basis of their function.
format	article
author	Cason R. King Ali Zhang Tanner M. Tessier Steven F. Gameiro Joe S. Mymryk
author_facet	Cason R. King Ali Zhang Tanner M. Tessier Steven F. Gameiro Joe S. Mymryk
author_sort	Cason R. King
title	Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
title_short	Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
title_full	Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
title_fullStr	Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
title_full_unstemmed	Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A
title_sort	hacking the cell: network intrusion and exploitation by adenovirus e1a
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/2f6c2011fd9c404c8566703b333ccfb0
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_version_	1718426956838469632

Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A

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