INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE

This study presents data upon the effects of CpG oligonucleotide substance (CpG ODN 2006). The commercial preparation was applied in vitro as a single agent, or in combination with various cytokine production inducers. Spontaneous and induced cytokine levels were tested in cultures of human blood ce...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. N. Klyueva, T. P. Shmelkova, T. N. Schukovskaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	vaccine oligodeoxynucleotide cpg odn 2006 cytokine production Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2f70e24f59f3496e92f5e4888e657b67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2f70e24f59f3496e92f5e4888e657b67
record_format	dspace
spelling	oai:doaj.org-article:2f70e24f59f3496e92f5e4888e657b672021-11-18T08:03:44ZINFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE1563-06252313-741X10.15789/1563-0625-2014-6-531-538https://doaj.org/article/2f70e24f59f3496e92f5e4888e657b672015-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/765https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThis study presents data upon the effects of CpG oligonucleotide substance (CpG ODN 2006). The commercial preparation was applied in vitro as a single agent, or in combination with various cytokine production inducers. Spontaneous and induced cytokine levels were tested in cultures of human blood cells taken from the persons before and after anti-plague vaccination. It has been shown that the vaccination had no effect upon spontaneous production of cytokines participating in innate (IL-8, TNFα) and adaptive (IFNγ, IL-4) immunity. CpG ODN 2006 proved to exert effects upon functional activity of human blood Th1 and Th2 pro-inflammatory cytokines after the first vaccination with live anti-plague vaccine, being reflected as higher Th1/ proinflammatory (IL-17 and IFNг) and Th2/ antiinflammatory (IL-4) cytokine production. Postvaccination changes of IgM, IgG, IgA, and IgE contents were non-significant. Following repeated vaccination, the CpG ODN 2006 induced an increase of IL-4 and IL-17 production in blood cells, as well as decrease in IFNг levels. Thus, the ability of CpG ODN 2006 to activate the cells participating in innate and adaptive immunity opens some prospects for usage of this oligodeoxynucleotide in the development of more efficient anti-plague vaccines.S. N. KlyuevaT. P. ShmelkovaT. N. SchukovskayaSPb RAACIarticlevaccineoligodeoxynucleotide cpg odn 2006cytokine productionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 6, Pp 531-538 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	vaccine oligodeoxynucleotide cpg odn 2006 cytokine production Immunologic diseases. Allergy RC581-607
spellingShingle	vaccine oligodeoxynucleotide cpg odn 2006 cytokine production Immunologic diseases. Allergy RC581-607 S. N. Klyueva T. P. Shmelkova T. N. Schukovskaya INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
description	This study presents data upon the effects of CpG oligonucleotide substance (CpG ODN 2006). The commercial preparation was applied in vitro as a single agent, or in combination with various cytokine production inducers. Spontaneous and induced cytokine levels were tested in cultures of human blood cells taken from the persons before and after anti-plague vaccination. It has been shown that the vaccination had no effect upon spontaneous production of cytokines participating in innate (IL-8, TNFα) and adaptive (IFNγ, IL-4) immunity. CpG ODN 2006 proved to exert effects upon functional activity of human blood Th1 and Th2 pro-inflammatory cytokines after the first vaccination with live anti-plague vaccine, being reflected as higher Th1/ proinflammatory (IL-17 and IFNг) and Th2/ antiinflammatory (IL-4) cytokine production. Postvaccination changes of IgM, IgG, IgA, and IgE contents were non-significant. Following repeated vaccination, the CpG ODN 2006 induced an increase of IL-4 and IL-17 production in blood cells, as well as decrease in IFNг levels. Thus, the ability of CpG ODN 2006 to activate the cells participating in innate and adaptive immunity opens some prospects for usage of this oligodeoxynucleotide in the development of more efficient anti-plague vaccines.
format	article
author	S. N. Klyueva T. P. Shmelkova T. N. Schukovskaya
author_facet	S. N. Klyueva T. P. Shmelkova T. N. Schukovskaya
author_sort	S. N. Klyueva
title	INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
title_short	INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
title_full	INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
title_fullStr	INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
title_full_unstemmed	INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
title_sort	influence of cpg odn 2006 oligodeoxynucleotide on cytokine production by blood cells of humans vaccinated against plague
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/2f70e24f59f3496e92f5e4888e657b67
work_keys_str_mv	AT snklyueva influenceofcpgodn2006oligodeoxynucleotideoncytokineproductionbybloodcellsofhumansvaccinatedagainstplague AT tpshmelkova influenceofcpgodn2006oligodeoxynucleotideoncytokineproductionbybloodcellsofhumansvaccinatedagainstplague AT tnschukovskaya influenceofcpgodn2006oligodeoxynucleotideoncytokineproductionbybloodcellsofhumansvaccinatedagainstplague
_version_	1718422407020019712

INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE

Ejemplares similares